Clinical and Translational Hepatology, Rajagiri Hospital, Aluva, Kerala, India
Department of Clinical Research, Rajagiri Hospital, Aluva, Kerala, India.
BMJ Case Rep. 2022 Mar 22;15(3):e247867. doi: 10.1136/bcr-2021-247867.
Hepatitis-associated aplastic anaemia (HAAA) is a rare condition characterised by onset of acute hepatitis which is followed by development of severe pancytopenia due to bone marrow failure within 6 months. This syndrome can be precipitated by acute viral infections, but the aetiology remains unknown in the majority. Drug-induced HAAA is extremely rare and has been reported with nutritional and dietary supplements in current literature. We report the first cases of ayurvedic herbal and homeopathic remedies-associated HAAA in two patients which proved fatal in both. Evaluation of patients with acute hepatitis and severe pancytopenia must include a detailed evaluation for complementary and alternative medicine use.
肝炎相关性再生障碍性贫血（HAAA）是一种罕见病症，其特征为急性肝炎发作，随后在 6 个月内由于骨髓衰竭而发展为严重全血细胞减少。该综合征可由急性病毒感染引发，但多数情况下病因不明。药物性 HAAA 极为罕见，目前文献中已有报道与营养和膳食补充剂相关。我们报告了两例阿育吠陀草药和顺势疗法药物相关 HAAA 的首例病例，这两例均致命。评估急性肝炎和严重全血细胞减少的患者必须包括对补充和替代医学使用的详细评估。
