Northern Finland Birth Cohort Center, University of Oulu, Oulu, FINLAND.
Research Unit of Medical Imaging, Physics and Technology (MIPT), University of Oulu, Oulu, FINLAND.
Med Sci Sports Exerc. 2022 Aug 1;54(8):1261-1270. doi: 10.1249/MSS.0000000000002916. Epub 2022 Mar 22.
Physical inactivity, excessive total time spent in sedentary behavior (SB) and prolonged sedentary bouts have been proposed to be risk factors for chronic disease morbidity and mortality worldwide. However, which patterns and postures of SB have the most negative impacts on health outcomes is still unclear. This population-based study aimed to investigate the independent associations of the patterns of accelerometer-based overall SB and sitting with serum lipid biomarkers at different moderate- to vigorous-intensity physical activity (MVPA) levels.
Physical activity and SB were measured in a birth cohort sample ( N = 3272) at 46 yr using a triaxial hip-worn accelerometer in free-living conditions for 14 d. Raw acceleration data were classified into SB and PA using a machine learning-based model, and the bouts of overall SB and sitting were identified from the classified data. The participants also answered health-related questionnaires and participated in clinical examinations. Associations of overall SB (lying and sitting) and sitting patterns with serum lipid biomarkers were investigated using linear regression.
The overall SB patterns were more consistently associated with serum lipid biomarkers than the sitting patterns after adjustments. Among the participants with the least and the most MVPA, high total time spent in SB and SB bouts of 15-29.99 and ≥30 min were associated with impaired lipid metabolism. Among those with moderate amount of MVPA, higher time spent in SB and SB bouts of 15-29.99 min was unfavorably associated with serum lipid biomarkers.
The associations between SB patterns and serum lipid biomarkers were dependent on MVPA level, which should be considered when planning evidence-based interventions to decrease SB in midlife.
身体活动不足、总久坐时间（SB）过长和长时间久坐已被提出是全球慢性病发病率和死亡率的危险因素。然而，哪种 SB 模式和姿势对健康结果的影响最大尚不清楚。本基于人群的研究旨在调查基于加速度计的整体 SB 和坐姿与不同中等至剧烈强度体力活动（MVPA）水平下血清脂质生物标志物之间的独立关联。
在自由生活条件下，使用三轴髋戴式加速度计在 46 岁时对出生队列样本（N=3272）进行 14 天的身体活动和 SB 测量。使用基于机器学习的模型对原始加速度数据进行分类，从分类数据中识别出整体 SB 和坐姿的爆发。参与者还回答了与健康相关的问卷并参加了临床检查。使用线性回归研究整体 SB（躺着和坐着）和坐姿模式与血清脂质生物标志物的关联。
调整后，整体 SB 模式与血清脂质生物标志物的关联比坐姿模式更一致。在 MVPA 最少和最多的参与者中，长时间久坐和 15-29.99 分钟和≥30 分钟的 SB 爆发与脂质代谢受损有关。在具有适量 MVPA 的参与者中，长时间久坐和 15-29.99 分钟的 SB 爆发与血清脂质生物标志物呈不利关联。
SB 模式与血清脂质生物标志物之间的关联取决于 MVPA 水平，在计划减少中年 SB 的循证干预措施时应考虑这一点。
