Kim Esther Eun Hwa, Kang Jihun
Department of Family Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea.
Central Institute for Medical Research, Kosin University Gospel Hospital, Busan, Korea.
Korean J Fam Med. 2022 Mar;43(2):132-140. doi: 10.4082/kjfm.20.0158. Epub 2022 Mar 17.
This study aimed to evaluate the association between complementary and alternative medicine (CAM) use and fear of cancer recurrence (FCR) among breast cancer survivors, using a validated multidimensional FCR-assessing instrument. Despite the debate over its medical effects, the use of CAM in breast cancer survivors is increasing.
We recruited 326 breast cancer survivors who had completed the primary cancer treatment. Information on CAM use was obtained using a self-administered questionnaire, and FCR was assessed using the Korean version of the FCR Inventory (FCRI). Multivariate linear regression analysis was performed to evaluate the association between CAM use and FCR.
CAM users had higher total FCR scores than CAM non-users after covariate adjustment (CAM users: 74.6 vs. CAM non-users: 68.7; P=0.047). Among the FCRI subscales, CAM users showed higher coping strategy scores (CAM users: 22.3 vs. CAM non-users: 20.6; P=0.034) in the multivariable adjusted analysis. The use of multiple types of CAM was associated with increased FCR in a dose-dependent manner (P=0.002).
Breast cancer survivors who used CAM had a higher FCR than CAM non-users. The dose-response relationship between the use of multiple types of CAM and FCR suggests that breast cancer survivors who use multiple types of CAM should be provided with appropriate psychological interventions to decrease FCR.
本研究旨在使用经过验证的多维癌症复发恐惧评估工具，评估补充替代医学（CAM）的使用与乳腺癌幸存者癌症复发恐惧（FCR）之间的关联。尽管对其医学效果存在争议，但乳腺癌幸存者中使用补充替代医学的人数仍在增加。
我们招募了326名完成原发性癌症治疗的乳腺癌幸存者。使用自填式问卷获取补充替代医学使用情况的信息，并使用癌症复发恐惧量表（FCRI）的韩语版本评估癌症复发恐惧。进行多变量线性回归分析以评估补充替代医学使用与癌症复发恐惧之间的关联。
在进行协变量调整后，使用补充替代医学的患者的癌症复发恐惧总分高于未使用者（使用补充替代医学的患者：74.6分，未使用者：68.7分；P=0.047）。在多变量调整分析中，在癌症复发恐惧量表的子量表中，使用补充替代医学的患者在应对策略方面得分更高（使用补充替代医学的患者：22.3分，未使用者：20.6分；P=0.034）。使用多种类型的补充替代医学与癌症复发恐惧增加呈剂量依赖性相关（P=0.002）。
使用补充替代医学的乳腺癌幸存者比未使用者有更高的癌症复发恐惧。多种类型补充替代医学的使用与癌症复发恐惧之间的剂量反应关系表明，应向使用多种类型补充替代医学的乳腺癌幸存者提供适当的心理干预，以降低癌症复发恐惧。
