Medical Center Kruunuhaka Oy, Kaisaniemenkatu 1Ba, Helsinki, Finland.
Mineraalilaboratorio Mila Oy, Helsinki, Finland.
Sci Rep. 2022 Mar 23;12(1):5008. doi: 10.1038/s41598-022-09131-x.
The assessments of malnutrition in adults with MUST or NRS-2002 criteria do not give a detailed insight into the sufficiency of micronutrients. Sufficiency assessment of essential micronutrients on the individual level can be achieved only with laboratory measurements. The aim of this study was to estimate long-term trends in micronutrient sufficiency in the Finnish population with regards to gender and sex covariates. We retrieved from the clinical laboratory database (n = 67,236) all results on whole blood Magnesium, (B-Mg), Manganese (B-Mn), Zinc (B-Zn), Selenium (B-Se) and Copper from erythrocytes (E-Cu) and fasting serum β-carotenes (fS-BKarot), vitamin A (fS-A-vit), coenzyme Q10 (Ubiquinone, fS-Q10) and serum vitamin D (S-D-25) from the database of clinical laboratory Mineraalilaboratorio Mila Oy from the years 1987-2020. A weak positive linear trend is seen for B-Mg, B-Zn and ln(fS-Q10) both for children and adults, but a moderate linear positive trend was observed for ln(S-D-25) based on correlation between calendar year and ln(S-D-25), R = 0.44 and 0.41, p < 0.001 for adults and children, respectively. Laboratory database is helpful to monitor the nutritional public policy to prevent hidden malnutrition in the society.
采用 MUST 或 NRS-2002 标准评估成年人的营养不良状况，并不能深入了解微量营养素的充足程度。只有通过实验室测量才能对个体水平的必需微量营养素的充足程度进行评估。本研究的目的是评估芬兰人口在性别和性别协变量方面的必需微量营养素长期趋势。我们从临床实验室数据库（n=67236）中检索了 1987 年至 2020 年期间来自临床实验室 Mineraalilaboratorio Mila Oy 的全血镁（B-Mg）、锰（B-Mn）、锌（B-Zn）、硒（B-Se）和红细胞铜（E-Cu）以及空腹血清 β-胡萝卜素（fS-BKarot）、维生素 A（fS-A-vit）、辅酶 Q10（泛醌，fS-Q10）和血清维生素 D（S-D-25）的所有结果。儿童和成人的 B-Mg、B-Zn 和 ln(fS-Q10) 均呈现出微弱的正线性趋势，但基于与日历年份的相关性，ln(S-D-25) 呈现出中度的正线性趋势，相关系数 R 分别为 0.44 和 0.41，p 值均小于 0.001。实验室数据库有助于监测营养公共政策，以防止社会中隐藏的营养不良。
