代谢组学有助于发现近视的代谢特征和途径：系统评价。
Metabolomics facilitates the discovery of metabolic profiles and pathways for myopia: A systematic review.
机构信息
School of Public Health, Medical College of Soochow University, Suzhou, China.
出版信息
Eye (Lond). 2023 Mar;37(4):670-677. doi: 10.1038/s41433-022-02019-0. Epub 2022 Mar 24.
BACKGROUND
Myopia is one of the major eye disorders and the global burden is increasing rapidly. Our purpose is to systematically summarize potential metabolic biomarkers and pathways in myopia to facilitate the understanding of disease mechanisms as well as the discovery of novel therapeutic measures.
METHODS
Myopia-related metabolomics studies were searched in electronic databases of PubMed and Web of Science until June 2021. Information regarding clinical and demographic characteristics of included studies and metabolomics findings were extracted. Myopia-related metabolic pathways were analysed for differential metabolic profiles, and the quality of included studies was assessed based on the QUADOMICS tool. Pathway analyses of differential metabolites were performed using bioinformatics tools and online software such as the Metaboanalyst 5.0.
RESULTS
The myopia-related metabolomics studies included in this study consisted of seven human and two animal studies. The results of the study quality assessment showed that studies were all phase I studies and all met the evaluation criteria of 70% or more. The myopia-control serum study identified 23 differential metabolites with the Sphingolipid metabolism pathway beings enriched. The high myopia-cataract aqueous humour study identified 40 differential metabolites with the Arginine biosynthesis pathway being enriched. The high myopia-control serum study identified 43 differential metabolites and 4 pathways were significantly associated with metabolites including Citrate cycle; Alanine, aspartate and glutamate metabolism; Glyoxylate and dicarboxylate metabolism; Biosynthesis of unsaturated fatty acids (all P value < 0.05).
CONCLUSIONS
This study summarizes potential metabolic biomarkers and pathways in myopia, providing new clues to elucidate disease mechanisms.
背景
近视是主要的眼部疾病之一，其全球负担正在迅速增加。我们的目的是系统地总结近视的潜在代谢生物标志物和途径，以促进对疾病机制的理解，并发现新的治疗措施。
方法
在 PubMed 和 Web of Science 的电子数据库中搜索与近视相关的代谢组学研究，直至 2021 年 6 月。提取纳入研究的临床和人口统计学特征以及代谢组学发现的信息。对近视相关代谢途径进行分析，以确定差异代谢图谱，并根据 QUADOMICS 工具评估纳入研究的质量。使用生物信息学工具和在线软件（如 Metaboanalyst 5.0）对差异代谢物进行途径分析。
结果
本研究纳入的近视相关代谢组学研究包括 7 项人类研究和 2 项动物研究。研究质量评估结果表明，所有研究均为 I 期研究，且均符合 70%或以上评估标准。近视控制血清研究确定了 Sphingolipid metabolism pathway 中 23 个差异代谢物。高度近视性白内障房水研究确定了 Arginine biosynthesis pathway 中 40 个差异代谢物。高度近视控制血清研究确定了 43 个差异代谢物和 4 条途径与代谢物显著相关，包括 Citrate cycle；Alanine, aspartate and glutamate metabolism；Glyoxylate and dicarboxylate metabolism；Biosynthesis of unsaturated fatty acids（均 P 值<0.05）。
结论
本研究总结了近视的潜在代谢生物标志物和途径，为阐明疾病机制提供了新的线索。
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