Grochowski Emil Tomasz, Pietrowska Karolina, Kowalczyk Tomasz, Mariak Zofia, Kretowski Adam, Ciborowski Michal, Dmuchowska Diana Anna
Department of Ophthalmology, Medical University of Bialystok, M. Sklodowskiej Curie 24a, 15-276 Bialystok, Poland.
Clinical Research Centre, Medical University of Bialystok, M. Sklodowskiej Curie 24a, 15-276 Bialystok, Poland.
J Clin Med. 2020 Oct 28;9(11):3464. doi: 10.3390/jcm9113464.
Myopia is a globally emerging issue, with multiple medical and socio-economic burdens and no well-established causal treatment thus far. A better insight into altered biochemical pathways and underlying pathogenesis might facilitate early diagnosis and treatment of myopia, ultimately leading to the development of more effective preventive and therapeutic measures. In this review, we summarize current data about the metabolomics and proteomics of myopia in humans and present various experimental approaches and animal models, along with their strengths and weaknesses. We also discuss the potential applicability of these findings to medical practice and suggest directions for future research.
近视是一个全球范围内日益凸显的问题，它带来了多种医学和社会经济负担，且迄今为止尚无成熟的病因治疗方法。更深入地了解生化途径的改变和潜在发病机制，可能有助于近视的早期诊断和治疗，最终推动更有效的预防和治疗措施的发展。在本综述中，我们总结了目前关于人类近视的代谢组学和蛋白质组学的数据，并介绍了各种实验方法和动物模型，以及它们的优缺点。我们还讨论了这些研究结果在医学实践中的潜在适用性，并提出了未来研究的方向。
