文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

了解针对 COVID-19 的 T 细胞反应对于制定公共卫生策略至关重要。

Understanding T cell responses to COVID-19 is essential for informing public health strategies.

机构信息

Lymphoma Service, Division of Hematologic Malignancies, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

出版信息

Sci Immunol. 2022 May 20;7(71):eabo1303. doi: 10.1126/sciimmunol.abo1303.

DOI:10.1126/sciimmunol.abo1303
PMID:35324269
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10344642/
Abstract

Durable T cell responses to SARS-CoV-2 antigens after infection or vaccination improve immune-mediated viral clearance. To date, population-based surveys of COVID-19 adaptive immunity have focused on testing for IgG antibodies that bind spike protein and/or neutralize the virus. Deployment of existing methods for measuring T cell immunity could provide a more complete profile of immune status, informing public health policies and interventions.

摘要

感染或接种 SARS-CoV-2 抗原后，对 SARS-CoV-2 抗原的持久 T 细胞反应可改善免疫介导的病毒清除。迄今为止，基于人群的 COVID-19 适应性免疫调查主要集中在检测与刺突蛋白结合和/或中和病毒的 IgG 抗体。部署现有的 T 细胞免疫检测方法可以更全面地了解免疫状态，为公共卫生政策和干预措施提供信息。

相似文献

[1]
Understanding T cell responses to COVID-19 is essential for informing public health strategies.

Sci Immunol. 2022-5-20

[2]
Longitudinal humoral and cell-mediated immune responses in a population-based cohort in Zurich, Switzerland between March and June 2022 - evidence for protection against Omicron SARS-CoV-2 infection by neutralizing antibodies and spike-specific T-cell responses.

Int J Infect Dis. 2023-8

[3]
Long-lasting T-cell response to SARS-CoV-2 antigens after vaccination-a prospective cohort study of HCWs working with COVID-19 patients.

Infect Dis (Lond). 2023-2

[4]
Induction of High Levels of Specific Humoral and Cellular Responses to SARS-CoV-2 After the Administration of Covid-19 mRNA Vaccines Requires Several Days.

Front Immunol. 2021

[5]
T-Cell Mediated Response after Primary and Booster SARS-CoV-2 Messenger RNA Vaccination in Nursing Home Residents.

J Am Med Dir Assoc. 2023-2

[6]
SARS-CoV-2 antibody and T cell responses one year after COVID-19 and the booster effect of vaccination: A prospective cohort study.

J Infect. 2022-2

[7]
High-Resolution Linear Epitope Mapping of the Receptor Binding Domain of SARS-CoV-2 Spike Protein in COVID-19 mRNA Vaccine Recipients.

Microbiol Spectr. 2021-12-22

[8]
Pre-existing immunity to SARS-CoV-2 associates with strong T cell responses induced by inactivated COVID-19 vaccines.

J Med Virol. 2023-3

[9]
Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patients.

PLoS One. 2022

[10]
Cellular and humoral responses after second and third SARS-CoV-2 vaccinations in patients with autoimmune diseases treated with rituximab: specific T cell immunity remains longer and plays a protective role against SARS-CoV-2 reinfections.

Front Immunol. 2023

引用本文的文献

[1]
Vaccination, infection, and hybrid immunity: determinants of SARS-CoV-2 IgG antibody levels and protection in Quzhou, China.

Front Immunol. 2025-7-28

[2]
Vaccine-induced T cell responses correlate with reduced risk of severe COVID-19 in a placebo-controlled efficacy trial.

EBioMedicine. 2025-7

[3]
Use of a Multiplex Immunoassay Platform to Investigate Multifaceted Antibody Responses in SARS-CoV-2 Vaccinees with and Without Prior Infection.

COVID. 2025-4

[4]
Immunologic Response and Effects of COVID-19 Vaccines in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Yonsei Med J. 2025-5

[5]
Novel Vaccines Targeting the Highly Conserved SARS-CoV-2 ORF3a Ectodomain Elicit Immunogenicity in Mouse Models.

Vaccines (Basel). 2025-2-22

[6]
Booster effect of the fourth dose of the SARS-CoV-2 mRNA vaccine in kidney transplant recipients.

Clin Exp Nephrol. 2025-3-11

[7]
Limitations of neutralizing antibody titers in COVID-19 vaccine efficacy trials and a call for additional correlates of protection.

Hum Vaccin Immunother. 2025-12

[8]
A randomized, double-blind, placebo-controlled trial of IL-7 in critically ill patients with COVID-19.

JCI Insight. 2025-2-4

[9]
NIAID Workshop Report: Systematic Approaches for ESKAPE Bacteria Antigen Discovery.

Vaccines (Basel). 2025-1-18

[10]
Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans.

Nat Microbiol. 2025-2

本文引用的文献

[1]
Clinical Validation of a Novel T-Cell Receptor Sequencing Assay for Identification of Recent or Prior Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

Clin Infect Dis. 2022-12-19

[2]
Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa.

Science. 2022-5-6

[3]
Humoral and T-cell responses to SARS-CoV-2 vaccination in multiple sclerosis patients treated with ocrelizumab.

Mult Scler Relat Disord. 2022-1

[4]
T cell responses to SARS-CoV-2 spike cross-recognize Omicron.

Nature. 2022-3

[5]
Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts.

Nat Commun. 2022-1-10

[6]
SARS-CoV-2 spreads through cell-to-cell transmission.

Proc Natl Acad Sci U S A. 2022-1-4

[7]
Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial.

Lancet. 2021-12-18

[8]
Evidence of SARS-CoV-2-Specific Memory B Cells Six Months After Vaccination With the BNT162b2 mRNA Vaccine.

Front Immunol. 2021

[9]
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern.

Science. 2021-12-3

[10]
Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months.

N Engl J Med. 2021-12-9

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索