Sastalla Inka, Kwon Keehwan, Huntley Clayton, Taylor Kimberly, Brown Liliana, Samuel Tamika, Zou Lanling
Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
Vaccines (Basel). 2025 Jan 18;13(1):87. doi: 10.3390/vaccines13010087.
On 14-15 November 2023, the National Institute of Allergy and Infectious Diseases (NIAID) organized a workshop entitled "Systematic Approaches for ESKAPE Bacteria Antigen Discovery". The goal of the workshop was to engage scientists from diverse relevant backgrounds to explore novel technologies that can be harnessed to identify and address current roadblocks impeding advances in antigen and vaccine discoveries for the ESKAPE pathogens (, , , , and species). The workshop consisted of four sessions that addressed ESKAPE infections, antigen discovery and vaccine efforts, and new technologies including systems immunology and vaccinology approaches. Each session was followed by a panel discussion. In total, there were over 260 in-person and virtual attendees, with high levels of engagement. This report provides a summary of the event and highlights challenges and opportunities in the field of ESKAPE vaccine discovery.
2023年11月14日至15日，美国国家过敏和传染病研究所（NIAID）组织了一次题为“ESKAPE细菌抗原发现的系统方法”的研讨会。该研讨会的目标是让来自不同相关背景的科学家参与进来，探索可用于识别和解决当前阻碍ESKAPE病原体（屎肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和阴沟肠杆菌）抗原和疫苗发现进展的新技术。研讨会包括四个环节，分别讨论了ESKAPE感染、抗原发现和疫苗研发工作，以及包括系统免疫学和疫苗学方法在内的新技术。每个环节之后都进行了小组讨论。总共有260多名现场和线上参会者，参与度很高。本报告总结了此次活动，并突出了ESKAPE疫苗发现领域的挑战和机遇。
