一种超支化聚甘油功能化聚合物极性固定相。
A hyperbranched polyglycerol-functionalized polymer polar stationary phase.
机构信息
Engineering Research Center of Pharmaceutical Process Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, 130 Meilong RD, Pharmacy School, East-China Univ. Sci. Tech., Shanghai 200237, China.
Engineering Research Center of Pharmaceutical Process Chemistry, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, 130 Meilong RD, Pharmacy School, East-China Univ. Sci. Tech., Shanghai 200237, China.
出版信息
J Chromatogr A. 2022 May 10;1670:462946. doi: 10.1016/j.chroma.2022.462946. Epub 2022 Mar 8.
A polymer polar stationary phase functionalized with hyperbranched polyglycerol for hydrophilic interaction chromatography (HILIC) is described. It is prepared via surface-initiated ring-opening polymerization of hyperbranched polyglycerol onto hydrolzed poly(glycidyl methacrylate-divinylbenzene) microspheres. The capacity of the functional groups can be maniputed by repeating hyperbranch layers. The phase showed typical HILIC character with good separation performance towards tested polar analytes. It also exhibited wider pH tolerance range (e.g. at least 2 to 12) and as well negligible bleed level under gradient elution mode (even to 50% fraction of water).
一种聚合物的极性固定相，通过超支化聚甘油的表面引发开环聚合作用键合到水解的聚（甲基丙烯酸缩水甘油酯-二乙烯基苯）微球上，从而用于亲水作用色谱（HILIC）。通过重复超支化层可以控制功能基团的容量。该固定相表现出典型的 HILIC 特性，对测试的极性分析物具有良好的分离性能。在梯度洗脱模式下，它还表现出更宽的 pH 容忍范围（例如至少 2 至 12）和几乎可以忽略的的洗脱水平（即使是 50%的水分数）。
Zotero 插件