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自身免疫性前庭病——病例系列

Autoimmune Vestibulopathy-A Case Series.

作者信息

Mendis Surangi, Longley Nicola, Morley Simon, Korres George, Kaski Diego

机构信息

Department of Neuro-Otology, Royal National ENT and Eastman Dental Hospitals, UCLH, London WC1E 6DG, UK.

Department of Neuro-Otology, St Ann's Hospital, Whittington Health NHS Trust, London N15 3TH, UK.

出版信息

Brain Sci. 2022 Feb 24;12(3):306. doi: 10.3390/brainsci12030306.

Abstract

Autoimmune inner ear disease (AIED) is a rare clinical entity. Its pathogenicity, heterogenous clinical presentation in the context of secondary systemic autoimmune disease and optimal treatment avenues remain poorly understood. Vestibular impairment occurring in the context of AIED is rarely subject to detailed investigation given that the auditory symptoms and their responsiveness to immunosuppression are the focus of the few proposed diagnostic criteria for AIED. We present three cases of vestibulopathy occurring in the context of autoimmune inner ear conditions, including the first known report of autoimmune inner ear pathology arising with a temporal association to administration of the Pfizer-BioNTech SARS-CoV2 vaccination. We review the available literature pertinent to each case and summarise the key learning points, highlighting the variable presentation of vestibular impairment in AIED.

摘要

自身免疫性内耳疾病(AIED)是一种罕见的临床病症。其致病性、在继发性全身性自身免疫性疾病背景下的异质性临床表现以及最佳治疗途径仍知之甚少。鉴于听觉症状及其对免疫抑制的反应性是少数几个提出的AIED诊断标准的重点,因此在AIED背景下发生的前庭功能损害很少受到详细研究。我们报告了3例在自身免疫性内耳疾病背景下发生的前庭病变病例,包括首例已知的与辉瑞-生物新技术公司的严重急性呼吸综合征冠状病毒2(SARS-CoV-2)疫苗接种存在时间关联的自身免疫性内耳病理报告。我们回顾了与每个病例相关的现有文献,并总结了关键的经验教训,强调了AIED中前庭功能损害的多样表现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8655/8946225/030f92ba3c49/brainsci-12-00306-g001.jpg

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