Kiel Ida Almenning, Jones Helen, Lionett Sofie, Røsbjørgen Ragnhild, Lydersen Stian, Vanky Eszter, Moholdt Trine
Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Department of Obstetrics and Gynecology, St. Olav's Hospital, Trondheim University Hospital, 7030 Trondheim, Norway.
J Clin Med. 2022 Mar 15;11(6):1626. doi: 10.3390/jcm11061626.
polycystic ovary syndrome (PCOS) is associated with cardiovascular disease (CVD) risk factors. First-line therapy for PCOS is lifestyle changes including exercise. We compared CVD risk factors between women with and without PCOS and examined the responses to high-intensity interval training (HIIT).
women with PCOS were randomized to HIIT ( = 41) or a non-exercise control group ( = 23) for 16 weeks. Women without PCOS ( = 15) were age- and BMI-matched to participants with PCOS and completed 16 weeks of HIIT. CVD markers included blood pressure, heart rate, flow mediated dilatation (FMD), carotid intima-media thickness (IMT), and circulating concentrations of lipids, glucose, insulin, and matrix metalloproteinase-9 (MMP-9).
resting heart rate was higher in women with PCOS than without PCOS ( =0.011) and was reduced after HIIT in women with PCOS (-2.8 beats/min, 95% CI: -5.4, -0.2, = 0.037). FMD was not significantly different between women with PCOS (5.5%, SD 4.1) and those without PCOS (8.2%, SD 3.9) at baseline. HIIT reduced time-to-peak dilatation of the brachial artery in women with PCOS compared with women without PCOS (-55 s, 95% CI: -96, -13, = 0.012).
we found little difference in CVD risk factors between women with and without PCOS at baseline, but some indications of endothelial dysfunction in women with PCOS.
多囊卵巢综合征（PCOS）与心血管疾病（CVD）风险因素相关。PCOS的一线治疗方法是生活方式改变，包括运动。我们比较了患有和未患有PCOS的女性之间的CVD风险因素，并研究了她们对高强度间歇训练（HIIT）的反应。
患有PCOS的女性被随机分为HIIT组（n = 41）或非运动对照组（n = 23），为期16周。未患有PCOS的女性（n = 15）在年龄和体重指数上与患有PCOS的参与者相匹配，并完成了16周的HIIT。CVD标志物包括血压、心率、血流介导的扩张（FMD）、颈动脉内膜中层厚度（IMT）以及脂质、葡萄糖、胰岛素和基质金属蛋白酶-9（MMP-9）的循环浓度。
患有PCOS的女性静息心率高于未患有PCOS的女性（P = 0.011），并且患有PCOS的女性在HIIT后静息心率降低（-2.8次/分钟，95%CI：-5.4，-0.2，P = 0.037）。在基线时，患有PCOS的女性（5.5%，标准差4.1）和未患有PCOS的女性（8.2%，标准差3.9）之间的FMD没有显著差异。与未患有PCOS的女性相比，HIIT减少了患有PCOS的女性肱动脉达到峰值扩张的时间（-55秒，95%CI：-96，-13，P = 0.012）。
我们发现基线时患有和未患有PCOS的女性之间在CVD风险因素方面差异不大，但有一些迹象表明患有PCOS的女性存在内皮功能障碍。
