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不同γ射线照射模式对可能影响雄性大鼠细胞周期进程因素的影响

The Influence of Different γ-Irradiation Patterns on Factors that May Affect Cell Cycle Progression in Male Rats.

作者信息

Mohammed Manal R, El-Bahkery Azza M, Shedid Shereen M

机构信息

Egyptian Atomic Energy Authority, Cairo, Egypt.

出版信息

Dose Response. 2022 Aug 11;20(3):15593258221117898. doi: 10.1177/15593258221117898. eCollection 2022 Jul-Sep.

DOI:10.1177/15593258221117898
PMID:35982824
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9379971/
Abstract

Most studies of the biological effects of ionizing radiation have been done on a single acute dose, while clinically and environmentally exposures occur under chronic/repetitive conditions. It is important to study effects of different patterns of ionizing radiation. In this study, a rat model was used to compare the effects of repetitive and acute exposure. Groups: (I) control, (II, III) were exposed to fractionated doses (1.5 GyX4) and (2 GyX4), respectively/24h interval, and (IV, V) were exposed to 6 Gy and 8 Gy of whole-body gamma irradiation, respectively. The gene expression of MAPT and tau phosphorylation increased in all irradiated groups but the gene expression of PKN not affected. TGFβ% increased at dose of 2 GyX4 only. In addition, the cell cycle was arrested in S phase. Micronucleus (MN) increased and cell proliferation decreased. In conclusion, the dose and pattern of ionizing radiation do not affect the MAPT and PKN gene expression, but TGF-β, p-tau, MN assay and cell proliferation are significantly affected. The dose of 2 GyX4 showed distinctive effect. Repetitive exposure may increase TGF-β%, which causes radio-resistance and, G2/M delay. Thus, the cell cycle could be regulated in a different manner according to the dose and pattern of irradiation.

摘要

大多数关于电离辐射生物学效应的研究都是针对单次急性剂量进行的，而在临床和环境中，暴露是在慢性/重复性条件下发生的。研究不同模式的电离辐射效应很重要。在本研究中，使用大鼠模型比较重复性暴露和急性暴露的效应。分组：（I）对照组，（II、III）分别以24小时间隔接受分次剂量照射（1.5 Gy×4）和（2 Gy×4），（IV、V）分别接受6 Gy和8 Gy的全身γ射线照射。所有照射组中MAPT的基因表达和tau磷酸化增加，但PKN的基因表达未受影响。仅在2 Gy×4剂量时TGFβ%增加。此外，细胞周期在S期停滞。微核（MN）增加，细胞增殖减少。总之，电离辐射的剂量和模式不影响MAPT和PKN基因表达，但TGF-β、p-tau、MN检测和细胞增殖受到显著影响。2 Gy×4剂量显示出独特的效应。重复性暴露可能会增加TGF-β%，这会导致放射抗性和G2/M期延迟。因此，细胞周期可能会根据照射剂量和模式以不同方式受到调节。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/22d972d5688e/10.1177_15593258221117898-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/b20b2d1b6aab/10.1177_15593258221117898-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/2d84c279a337/10.1177_15593258221117898-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/34f523fe94bd/10.1177_15593258221117898-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/0da055fe721b/10.1177_15593258221117898-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/6d69190c8c5a/10.1177_15593258221117898-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/8a48baaa117c/10.1177_15593258221117898-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/c026a003f295/10.1177_15593258221117898-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/a9a87a43494c/10.1177_15593258221117898-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/22d972d5688e/10.1177_15593258221117898-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/b20b2d1b6aab/10.1177_15593258221117898-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/2d84c279a337/10.1177_15593258221117898-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/34f523fe94bd/10.1177_15593258221117898-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/0da055fe721b/10.1177_15593258221117898-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/6d69190c8c5a/10.1177_15593258221117898-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/8a48baaa117c/10.1177_15593258221117898-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/c026a003f295/10.1177_15593258221117898-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/a9a87a43494c/10.1177_15593258221117898-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/533c/9379971/22d972d5688e/10.1177_15593258221117898-fig9.jpg

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