Lin Ying-Chun, Huang Shan-Shan, Yen Cheng-Wei, Kabasawa Yuji, Lee Chien-Hung, Huang Hsiao-Ling
Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Department of Oral Hygiene, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
J Pers Med. 2022 Mar 14;12(3):459. doi: 10.3390/jpm12030459.
Late-life depression is a major mental health problem and constitutes a heavy public health burden. Frailty, an aging-related syndrome, is reciprocally related to depressive symptoms. This study investigated the associations of physical frailty and oral frailty with depression in older adults. This large-scale cross-sectional study included 1100 community-dwelling older adults in Taiwan. The participants completed a dental examination and questionnaires answered during personal interviews. The 15-item Geriatric Depression Scale was used to assess depression, and information on physical conditions and oral conditions was collected. Multivariable logistical regression analysis was conducted to examine associations of interest. Significant factors associated with depression were pre-physical frailty (adjusted odds ratio (aOR) = 3.61), physical frailty (aOR = 53.74), sarcopenia (aOR = 4.25), insomnia (aOR = 2.56), pre-oral frailty (aOR = 2.56), oral frailty (aOR = 4.89), dysphagia (aOR = 2.85), and xerostomia (aOR = 1.10). Depression exerted a combined effect on physical frailty and oral frailty (aOR = 36.81). Physical frailty and oral frailty were significantly associated with late-life depression in community-dwelling older adults in a dose-response manner. Developing physical and oral function interventions to prevent depression among older adults is essential.
老年期抑郁症是一个主要的心理健康问题，构成了沉重的公共卫生负担。衰弱是一种与衰老相关的综合征，与抑郁症状相互关联。本研究调查了身体衰弱和口腔衰弱与老年人抑郁症之间的关联。这项大规模横断面研究纳入了台湾1100名社区居住的老年人。参与者完成了牙科检查以及在个人访谈中回答的问卷。使用15项老年抑郁量表评估抑郁状况，并收集有关身体状况和口腔状况的信息。进行多变量逻辑回归分析以检验感兴趣的关联。与抑郁症相关的显著因素包括身体衰弱前期（调整后的优势比[aOR]=3.61）、身体衰弱（aOR=53.74）、肌肉减少症（aOR=4.25）、失眠（aOR=2.56）、口腔衰弱前期（aOR=2.56）、口腔衰弱（aOR=4.89）、吞咽困难（aOR=2.85）和口干（aOR=1.10）。抑郁症对身体衰弱和口腔衰弱有综合影响（aOR=36.81）。身体衰弱和口腔衰弱与社区居住老年人的老年期抑郁症呈显著的剂量反应关系。开展身体和口腔功能干预措施以预防老年人抑郁症至关重要。
