Faculty of Medicine and Health Science, Rovira I Virgili University, Tarragona, Spain.
Nutrition and Mental Health Research Group (NUTRISAM), URV, Reus, Spain.
Curr Nutr Rep. 2022 Jun;11(2):283-300. doi: 10.1007/s13668-022-00410-7. Epub 2022 Mar 25.
The aim is to examine data from clinical trials and prospective longitudinal studies that evaluate the effect of infant formula supplements on the cognitive function of children.
A total of 300 articles from 2000 to 2021 were selected. The most researched IF supplements were initially long-chain polyunsaturated fatty acids (LC-PUFA), some proteins and, recently, milk fat globule membrane (MFGM). Supplementation of IF with LC-PUFA led to some positive effects on specific cognitive functions or no effect; however, there was no consistent benefit for cognitive function. Modifying the amount of proteins did not affect the children's neuropsychological tests. Supplementation of IF with MFGM and its components had beneficial effects on child cognitive development in the short term, but no effect was observed in the long term. Further studies are needed to confirm the safety of supplementation on the development of cognitive function in children fed with infant formula.
本次综述旨在研究临床试验和前瞻性纵向研究的数据，评估婴儿配方奶粉补充剂对儿童认知功能的影响。
从 2000 年至 2021 年共选取了 300 篇文章。最初研究最多的 IF 补充剂是长链多不饱和脂肪酸（LC-PUFA）、一些蛋白质，最近则是乳脂肪球膜（MFGM）。IF 补充 LC-PUFA 对特定认知功能有一些积极影响或没有影响；但是，对认知功能没有一致的益处。改变蛋白质的数量不会影响儿童的神经心理学测试。IF 补充 MFGM 及其成分对儿童短期认知发展有有益影响，但长期观察则没有效果。需要进一步研究来确认补充 MFGM 及其成分对婴儿配方喂养的儿童认知功能发展的安全性。
