Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Department of Women's Health, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Nutrients. 2022 Mar 14;14(6):1226. doi: 10.3390/nu14061226.
This study investigated the relationship between headache and dietary consumption of a variety of nutrients in middle-aged women. This cross-sectional analysis used first-visit records of 405 women aged 40-59 years. The frequency of headaches was assessed using the Menopausal Health-Related Quality of Life Questionnaire. Of the 43 major nutrient intakes surveyed using the brief-type self-administered diet history questionnaire, those that were not shared between women with and without frequent headaches were selected. Multiple logistic regression analysis was used to identify nutrients independently associated with frequent headaches. After adjusting for background factors related to frequent headache (vasomotor, insomnia, anxiety, and depression symptoms), the estimated dietary intake of isoflavones (daidzein + genistein) (mg/1000 kcal/day) was negatively associated with frequent headaches (adjusted odds, 0.974; 95% confidence interval, 0.950-0.999). Moreover, the estimated isoflavone intake was not significantly associated with headache frequency in the premenopausal group, whereas it significantly correlated with that in the peri- and post-menopausal groups. Headache in peri- and post-menopausal women was inversely correlated with the dietary intake of isoflavones. Diets rich in isoflavones may improve headaches in middle-aged women.
本研究调查了中年女性头痛与各种营养素饮食摄入之间的关系。这项横断面分析使用了 405 名年龄在 40-59 岁的女性的首次就诊记录。使用绝经相关生活质量问卷评估头痛频率。在使用简短型自我管理饮食史问卷调查的 43 种主要营养素摄入中，选择了在有和无频繁头痛的女性之间没有共享的营养素。使用多变量逻辑回归分析确定与频繁头痛独立相关的营养素。在调整与频繁头痛相关的背景因素（血管舒缩、失眠、焦虑和抑郁症状）后，异黄酮（大豆苷元+染料木黄酮）的估计饮食摄入量（mg/1000 千卡/天）与频繁头痛呈负相关（调整后的比值比，0.974；95%置信区间，0.950-0.999）。此外，异黄酮的估计摄入量与绝经前组的头痛频率无显著相关性，而与绝经后组的头痛频率显著相关。围绝经期和绝经后妇女的头痛与异黄酮的饮食摄入量呈负相关。富含异黄酮的饮食可能会改善中年女性的头痛。
