Al-Hamidhi Salama, Parveen Asia, Iqbal Furhan, Asif Muhammad, Akhtar Naheed, Elshafie Elshafie I, Beja-Pereira Albano, Babiker Hamza A
Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.
Institute of Pure and Applied Biology, Zoology Division, Bahauddin Zakariya University, Multan 60800, Pakistan.
Pathogens. 2022 Mar 10;11(3):334. doi: 10.3390/pathogens11030334.
is a tick-borne protozoan parasite responsible for bovine theileriosis, a disease that impacts cattle population in many developing countries. Development and deployment of effective control strategies, based on vaccine or therapy, should consider the extent of diversity of the parasite and its population structure in different endemic areas. In this study, we examined in Pakistan and carried out a comparative analysis with similar data garneted in other areas, to provide further information on the level of parasite diversity and parasite genetic structure in different endemic areas.
The present study examined a set of 10 microsatellites/minisatellites and analyzed the genetic structure of in cattle breeds from Pakistan (Indian sub-continent) and compared these with those in Oman (Middle East), Tunisia (Africa), and Turkey (Europe).
A high level of genetic diversity was observed among detected in cattle from Pakistan, comparable to that in Oman, Tunisia, and Turkey. The genotypes of in these four countries form genetically distinct groups that are geographically sub-structured. The population in Oman overlapped with that in the Indian Subcontinent (Pakistan) and that in Africa (Tunisia).
The parasite in Pakistan is highly diverse, and genetically differentiated. This pattern accords well and complements that seen among representing the global endemic site. The parasite population in the Arabian Peninsula overlapped with that in the Indian-Subcontinent (India) and that in Africa (Tunisia), which shared some genotypes with that in the Near East and Europe (Turkey). This suggests some level of parasite gene flow, indicative of limited movement between neighboring countries.
是一种蜱传播的原生动物寄生虫，可引发牛泰勒虫病，这种疾病在许多发展中国家影响着牛群数量。基于疫苗或治疗的有效控制策略的开发和应用，应考虑寄生虫的多样性程度及其在不同流行地区的种群结构。在本研究中，我们对巴基斯坦的进行了检测，并与其他地区收集的类似数据进行了比较分析，以提供关于不同流行地区寄生虫多样性水平和寄生虫遗传结构的更多信息。
本研究检测了一组10个微卫星/小卫星，并分析了来自巴基斯坦（印度次大陆）牛品种中的遗传结构，并将其与阿曼（中东）、突尼斯（非洲）和土耳其（欧洲）的进行了比较。
在巴基斯坦牛中检测到的之间观察到高度的遗传多样性，与阿曼、突尼斯和土耳其的相当。这四个国家中的基因型形成了地理上亚结构化的遗传上不同的群体。阿曼的种群与印度次大陆（巴基斯坦）和非洲（突尼斯）的种群重叠。
巴基斯坦的寄生虫高度多样且在遗传上有差异。这种模式与代表全球流行地点的中所见模式非常吻合且互为补充。阿拉伯半岛的寄生虫种群与印度次大陆（印度）和非洲（突尼斯）的种群重叠，它们与近东和欧洲（土耳其）的种群共享一些基因型。这表明存在一定程度的寄生虫基因流动，表明邻国之间的移动有限。
