Munir Muhammad Usman, Ahmad Muhammad Masood
Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72388, Aljouf, Saudi Arabia.
Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72388, Aljouf, Saudi Arabia.
Pharmaceutics. 2022 Mar 7;14(3):582. doi: 10.3390/pharmaceutics14030582.
The global health of humans is seriously affected by the dramatic increases in the resistance patterns of antimicrobials against virulent bacteria. From the statements released by the Centers for Disease Control and Prevention about the world entering a post-antibiotic era, and forecasts about human mortality due to bacterial infection being increased compared to cancer, the current body of literature indicates that emerging tools such as nanoparticles can be used against lethal infections caused by bacteria. Furthermore, a different concept of nanomaterial-based methods can cope with the hindrance faced by common antimicrobials, such as resistance to antibiotics. The current review focuses on different approaches to inhibiting bacterial infection using nanoparticles and aiding in the fabrication of antimicrobial nanotherapeutics by emphasizing the functionality of nanomaterial surface design and fabrication for antimicrobial cargo.
抗菌药物对致病性细菌的耐药模式急剧增加，严重影响了全球人类健康。从美国疾病控制与预防中心发布的关于世界进入后抗生素时代的声明，以及关于细菌感染导致的人类死亡率相比癌症有所增加的预测来看，当前的文献表明，纳米颗粒等新兴工具可用于对抗由细菌引起的致命感染。此外，基于纳米材料的方法的不同概念可以应对普通抗菌药物所面临的障碍，如对抗生素的耐药性。本综述重点关注使用纳米颗粒抑制细菌感染的不同方法，并通过强调纳米材料表面设计和抗菌药物制备的功能，助力抗菌纳米疗法的制备。
