Meissner Katharina, Sauter-Louis Carola, Heiden Stefan E, Schaufler Katharina, Tomaso Herbert, Conraths Franz J, Homeier-Bachmann Timo
Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Epidemiology, 17493 Greifswald-Insel Riems, Germany.
Institute of Pharmacy, University of Greifswald, 17489 Greifswald, Germany.
Microorganisms. 2022 Mar 11;10(3):603. doi: 10.3390/microorganisms10030603.
Antimicrobial resistance is an increasing global problem and complicates successful treatments of bacterial infections in animals and humans. We conducted a longitudinal study in Mecklenburg-Western Pomerania to compare the occurrence of ESBL-producing ( in three conventional and four organic pig farms. ESBL-positive , especially of the CTX-M type, were found in all fattening farms, confirming that antimicrobial resistance is widespread in pig fattening and affects both conventional and organic farms. The percentage of ESBL-positive pens was significantly higher on conventional (55.2%) than on organic farms (44.8%) with similar proportions of ESBL-positive pens on conventional farms (54.3-61.9%) and a wide variation (7.7-84.2%) on organic farms. Metadata suggest that the farms of origin, from which weaner pigs were purchased, had a major influence on the occurrence of ESBL-producing in the fattening farms. Resistance screening showed that the proportion of pens with multidrug-resistant was similar on conventional (28.6%) and organic (31.5%) farms. The study shows that ESBL-positive play a major role in pig production and that urgent action is needed to prevent their spread.
抗菌药物耐药性是一个日益严重的全球性问题，使动物和人类细菌感染的成功治疗变得复杂。我们在梅克伦堡-前波美拉尼亚进行了一项纵向研究，以比较三个传统猪场和四个有机猪场中产超广谱β-内酰胺酶（ESBL）细菌的出现情况。在所有育肥猪场中均发现了ESBL阳性细菌，尤其是CTX-M型，这证实了抗菌药物耐药性在猪育肥中广泛存在，并且影响传统猪场和有机猪场。传统猪场中ESBL阳性猪栏的百分比（55.2%）显著高于有机猪场（44.8%），传统猪场中ESBL阳性猪栏的比例相似（54.3 - 61.9%），而有机猪场的比例差异较大（7.7 - 84.2%）。元数据表明，购买断奶仔猪的原猪场对育肥猪场中产ESBL细菌的出现有重大影响。耐药性筛查显示，传统猪场（28.6%）和有机猪场（31.5%）中多重耐药细菌猪栏的比例相似。该研究表明，ESBL阳性细菌在生猪生产中起主要作用，需要采取紧急行动以防止其传播。
