Rouchouse B, Bonnefoy M, Pallot B, Jacquelin L, Dimoux-Dime G, Claudy A L
Dermatologica. 1986;173(4):180-4. doi: 10.1159/000249246.
Three patients with acute generalized exanthematous pustular dermatitis (AGEPD) are presented. This new clinical entity comprises generalized erythema, erythema multiforme, amicrobial pustules, fever and spontaneous healing over a 10-day period. Histologically, there are a mixed neutrophilic and eosinophilic vasculitis and an eosinophilic subcorneal and spongiform pustule. All the patients experienced pharyngitis 1 week before the onset of the rash. Two of them had high-titered IgM-neutralizing antibodies to enteroviruses and 1 had an enterovirus in stool and urine. AGEPD may be related to a viral infection and may occur in patients with a genetic predisposition to psoriasis. The diagnosis of AGEPD should be made early enough so that the patients are not given the often aggressive therapy of pustular psoriasis.
本文报告了3例急性泛发性脓疱性皮病（AGEPD）患者。这种新的临床病症包括全身性红斑、多形红斑、无菌性脓疱、发热，并在10天内自愈。组织学上，有中性粒细胞和嗜酸性粒细胞混合性血管炎以及嗜酸性角质层下和海绵状脓疱。所有患者在皮疹发作前1周均出现咽炎。其中2例对肠道病毒有高滴度IgM中和抗体，1例粪便和尿液中检出肠道病毒。AGEPD可能与病毒感染有关，可能发生在有银屑病遗传易感性的患者中。应尽早做出AGEPD的诊断，以免患者接受通常用于脓疱型银屑病的激进治疗。
