Solari Eleonora, Marcozzi Cristiana, Ottaviani Chiara, Negrini Daniela, Moriondo Andrea
Department of Medicine and Surgery, School of Medicine, University of Insubria, 21100 Varese, Italy.
Biology (Basel). 2022 Mar 10;11(3):419. doi: 10.3390/biology11030419.
Lymphatic vessels exploit the mechanical stresses of their surroundings together with intrinsic rhythmic contractions to drain lymph from interstitial spaces and serosal cavities to eventually empty into the blood venous stream. This task is more difficult when the liquid to be drained has a very subatmospheric pressure, as it occurs in the pleural cavity. This peculiar space must maintain a very low fluid volume at negative hydraulic pressure in order to guarantee a proper mechanical coupling between the chest wall and lungs. To better understand the potential for liquid drainage, the key parameter to be considered is the difference in hydraulic pressure between the pleural space and the lymphatic lumen. In this review we collected old and new findings from in vivo direct measurements of hydraulic pressures in anaesthetized animals with the aim to better frame the complex physiology of diaphragmatic and intercostal lymphatics which drain liquid from the pleural cavity.
淋巴管利用周围环境的机械应力以及内在的节律性收缩，将淋巴从组织间隙和浆膜腔引流出来，最终排入血液静脉流。当要引流的液体处于极低的负压时，这项任务会更加困难，就像在胸腔中那样。这个特殊的腔隙必须在负液压下保持非常低的液体量，以确保胸壁和肺之间有适当的机械耦合。为了更好地理解液体引流的潜力，需要考虑的关键参数是胸膜腔和淋巴管腔之间的液压差。在这篇综述中，我们收集了对麻醉动物进行液压直接活体测量的新旧发现，目的是更好地梳理从胸腔引流液体的膈肌和肋间淋巴管的复杂生理学。
