Division of Cardiovascular Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA.
Department of Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA.
Curr Cardiol Rep. 2024 Nov;26(11):1209-1219. doi: 10.1007/s11886-024-02120-8. Epub 2024 Aug 22.
This review delves into recent advancements in understanding generalized and organ-specific lymphatic development. It emphasizes the distinct characteristics and critical anomalies that can impair lymphatic function. By exploring developmental mechanisms, the review seeks to illuminate the profound impact of lymphatic malformations on overall health and disease progression.
The introduction of genome sequencing, single-cell transcriptomic analysis, and advanced imaging technologies has significantly enhanced our ability to identify and characterize developmental defects within the lymphatic system. As a result, a wide range of lymphatic anomalies have been uncovered, spanning from congenital abnormalities present at birth to conditions that can become life-threatening in adulthood. Additionally, recent research highlights the heterogeneity of lymphatics, revealing organ-specific developmental pathways, unique molecular markers, and specialized physiological functions specific to each organ. A deeper understanding of the unique characteristics of lymphatic cell populations in an organ-specific context is essential for guiding future research into lymphatic disease processes. An integrated approach to translational research could revolutionize personalized medicine, where treatments are precisely tailored to individual lymphatic profiles, enhancing effectiveness and minimizing side effects.
本文深入探讨了广义和器官特异性淋巴系统发育的最新研究进展。强调了不同的特征和关键异常，这些异常可能会损害淋巴功能。通过探索发育机制，本综述旨在阐明淋巴畸形对整体健康和疾病进展的深远影响。
基因组测序、单细胞转录组分析和先进的成像技术的引入，极大地提高了我们识别和描述淋巴系统发育缺陷的能力。因此，已经发现了广泛的淋巴异常，从出生时存在的先天性异常到成年后可能危及生命的疾病。此外，最近的研究强调了淋巴管的异质性，揭示了器官特异性发育途径、独特的分子标记物以及每个器官特有的专门生理功能。深入了解特定器官中淋巴管细胞群体的独特特征，对于指导未来的淋巴疾病过程研究至关重要。转化研究的综合方法可能会彻底改变个性化医疗，使治疗精确地针对个体的淋巴特征，提高疗效并最大限度地减少副作用。
