Speeckaert Nathanaël, El Jaziri Mondher, Baucher Marie, Behr Marc
Laboratoire de Biotechnologie Végétale, Université libre de Bruxelles (ULB), Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium.
Biology (Basel). 2022 Mar 14;11(3):441. doi: 10.3390/biology11030441.
Plants have developed the capacity to produce a diversified range of specialized metabolites. The glycosylation of those metabolites potentially decreases their toxicity while increasing their stability and their solubility, modifying their transport and their storage. The UGT, forming the largest glycosyltransferase superfamily in plants, combine enzymes that glycosylate mainly hormones and phenylpropanoids by using UDP-sugar as a sugar donor. Particularly, members of the UGT72 family have been shown to glycosylate the monolignols and the flavonoids, thereby being involved in their homeostasis. First, we explore primitive UGTs in algae and liverworts that are related to the angiosperm UGT72 family and their role in flavonoid homeostasis. Second, we describe the role of several UGT72s glycosylating monolignols, some of which have been associated with lignification. In addition, the role of other UGT72 members that glycosylate flavonoids and are involved in the development and/or stress response is depicted. Finally, the importance to explore the subcellular localization of UGTs to study their roles in planta is discussed.
植物已发展出产生多种特殊代谢产物的能力。这些代谢产物的糖基化可能会降低其毒性，同时提高其稳定性和溶解性，改变其运输和储存方式。UGT构成了植物中最大的糖基转移酶超家族，它结合了主要通过使用UDP-糖作为糖供体对激素和苯丙烷类进行糖基化的酶。特别地，UGT72家族的成员已被证明可对单木质醇和类黄酮进行糖基化，从而参与它们的体内平衡。首先，我们探索藻类和地钱中与被子植物UGT72家族相关的原始UGT及其在类黄酮体内平衡中的作用。其次，我们描述了几种对单木质醇进行糖基化的UGT72的作用，其中一些与木质化有关。此外，还描述了其他对类黄酮进行糖基化并参与发育和/或应激反应的UGT72成员的作用。最后，讨论了探索UGT亚细胞定位以研究其在植物中的作用的重要性。
