在有或无大肠杆菌内毒素存在的情况下，大鼠肾小管对庆大霉素和妥布霉素的体外摄取。

In-vitro uptake of gentamicin and tobramycin by rat renal tubules in the presence or absence of Escherichia coli endotoxin.

作者信息

Bergeron M G, Lessard C, Turcotte A

出版信息

J Antimicrob Chemother. 1986 Sep;18(3):375-80. doi: 10.1093/jac/18.3.375.

DOI:10.1093/jac/18.3.375

Abstract

Renal tubules of rats were incubated with aminoglycoside (gentamicin or 3H-tobramycin, 10 mg/l) in the presence or absence of Escherichia coli endotoxin (10 mg/l). The kinetics of aminoglycoside uptake by the tubule were only slightly affected by endotoxin. The percentage of serum in the medium affected the tobramycin uptake. This uptake decreased from a mean ratio of concentration in the tubules/concentration in the medium (T/M) of 1.63 in 5% serum to a mean T/M of 0.86 in 10% serum (P less than 0.01).

摘要

将大鼠肾小管在有或无大肠杆菌内毒素（10毫克/升）存在的情况下，与氨基糖苷类药物（庆大霉素或3H - 妥布霉素，10毫克/升）一起孵育。内毒素对肾小管摄取氨基糖苷类药物的动力学影响很小。培养基中血清的百分比影响妥布霉素的摄取。这种摄取从5%血清中肾小管浓度/培养基浓度的平均比值（T/M）1.63降至10%血清中的平均T/M 0.86（P小于0.01）。