人类疾病猪模型的研究进展。
Advances in pig models of human diseases.
机构信息
College of Animal Science and Technology, China Agricultural University, Beijing, China.
Sanya Institute of China Agricultural University, Sanya, China.
出版信息
Animal Model Exp Med. 2022 Apr;5(2):141-152. doi: 10.1002/ame2.12223. Epub 2022 Mar 27.
Abstract
Animal models of human diseases play a critical role in medical research. Pigs are anatomically and physiologically more like humans than are small rodents such as mice, making pigs an attractive option for modeling human diseases. Advances in recent years in genetic engineering have facilitated the rapid rise of pig models for use in studies of human disease. In the present review, we summarize the current status of pig models for human cardiovascular, metabolic, neurodegenerative, and various genetic diseases. We also discuss areas that need to be improved. Animal models of human diseases play a critical role in medical research. Advances in recent years in genetic engineering have facilitated the rapid rise of pig models for use in studies of human disease. In the present review, we summarize the current status of pig models for human cardiovascular, metabolic, neurodegenerative, various genetic diseases and xenotransplantation.
摘要
动物疾病模型在医学研究中起着至关重要的作用。猪在解剖学和生理学上比小啮齿动物（如老鼠）更像人类，因此成为人类疾病建模的理想选择。近年来，遗传工程学的进步促进了猪模型在人类疾病研究中的快速发展。在本综述中，我们总结了目前用于人类心血管、代谢、神经退行性和各种遗传疾病以及异种移植的猪模型的现状。我们还讨论了需要改进的领域。
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