Zhang J, Shen W W, Gao M Y, Ding Y Y, He N, Lin H J, Chen X X, Liu Xing
Department of Epidemiology/Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China.
Taizhou City Center for Disease Control and Prevention, Taizhou 318000, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2022 Mar 10;43(3):380-386. doi: 10.3760/cma.j.cn112338-20210720-00570.
To explore the correlation between club drug use and anal canal human papillomavirus (HPV) infection in HIV-negative and HIV-positive men who have sex with men (MSM) in Taizhou. A cross-sectional survey was conducted in Taizhou. HIV-negative MSM were recruited by convenient sampling in voluntary counseling and testing clinics of Taizhou prefectural CDC from August 2016 to October 2017, and HIV-positive MSM were recruited through the routine follow-up and management by Taizhou prefectural CDC from August 2016 to June 2019. A face-to-face questionnaire interview was conducted to collect the information about the socio-demographic characteristics, sexual orientation, sexual behavior, club drug use and other information of the participants. Anal canal swabs were collected for HPV genotyping. The correlation between club drug use and the prevalence of HPV infection were evaluated with test and logistic regression analysis. A total of 69 HIV-negative and 345 HIV-infected MSM were included. The prevalence of any type of anal canal HPV infection in HIV-negative MSM (27.5%, 19/69) was lower than that in HIV-positive MSM (66.4%, 229/345) (=36.114,<0.001). The prevalence of self-reported club drug use in HIV-negative MSM was higher (17.4%, 12/69) than that in HIV-positive MSM (7.0%, 24/345) (=7.886, =0.005). For HIV-negative MSM, the prevalence of club drug use was higher in MSM who had homosexual group sex (=0.036); the prevalence of HPV infection was 50.0% (6/12) in club drug users and 22.8% (13/57) in non-club drug users (=3.674, =0.055). For HIV-positive MSM, the prevalence of HPV infection was 70.8% (17/24) in club drug users and 66.0% (212/321) in non-club drug users (=0.230, =0.632). Multivariable logistic regression model showed that HPV infection in MSM was positively correlated with HIV infection (=5.42, 95%: 2.92-10.06), and the association between HPV infection and club drug use (=1.66, 95%: 0.75-3.71) was not significant. HIV infection was positively correlated with anal canal HPV infection in MSM in Taizhou. Club drug use was positively correlated with high-risk sexual behaviors, while its association with HPV infection needs further study.
探索台州市男男性行为者（MSM）中，HIV阴性和HIV阳性人群使用新型毒品与肛管人乳头瘤病毒（HPV）感染之间的相关性。在台州市开展了一项横断面调查。2016年8月至2017年10月，通过台州市疾控中心自愿咨询检测门诊便利抽样招募HIV阴性MSM；2016年8月至2019年6月，通过台州市疾控中心常规随访管理招募HIV阳性MSM。进行面对面问卷调查，收集参与者的社会人口学特征、性取向、性行为、新型毒品使用等信息。采集肛管拭子进行HPV基因分型。采用检验和逻辑回归分析评估新型毒品使用与HPV感染患病率之间的相关性。共纳入69名HIV阴性和345名HIV感染的MSM。HIV阴性MSM中任何类型肛管HPV感染的患病率（27.5%，19/69）低于HIV阳性MSM（66.4%，229/345）（=36.114，<0.001）。HIV阴性MSM中自我报告的新型毒品使用率（17.4%，12/69）高于HIV阳性MSM（7.0%，24/345）（=7.886，=0.005）。对于HIV阴性MSM，有男同性恋群交行为的MSM新型毒品使用率更高（=0.036）；新型毒品使用者中HPV感染患病率为50.0%（6/12），非新型毒品使用者中为22.8%（13/57）（=3.674，=0.055）。对于HIV阳性MSM，新型毒品使用者中HPV感染患病率为70.8%（17/24），非新型毒品使用者中为66.0%（212/321）（=0.230，=0.632）。多变量逻辑回归模型显示，MSM中HPV感染与HIV感染呈正相关（=5.42，95%：2.92 - 10.06），HPV感染与新型毒品使用之间的关联（=1.66，95%：0.75 - 3.71）不显著。台州市MSM中HIV感染与肛管HPV感染呈正相关。新型毒品使用与高危性行为呈正相关，但其与HPV感染的关联有待进一步研究。
