Center for AIDS Intervention Research (CAIR), Department of Psychiatry and Behavioural Medicine, 5506Medical College of Wisconsin, Milwaukee, WI, USA.
Clinical Cancer Center, 5506Medical College of Wisconsin, Milwaukee, WI, USA.
Int J STD AIDS. 2022 Jun;33(7):672-679. doi: 10.1177/09564624221094456. Epub 2022 May 7.
Anal cancer is primarily caused by high-risk human papillomavirus (hrHPV), is associated with HIV infection, and has a very high incidence among men who have sex with men (MSM). We assessed prevalence of hrHPV, and factors associated with hrHPV in anal canal specimens collected in Dar es Salaam, Tanzania from HIV-positive and HIV-negative MSM. MSM were recruited using respondent-driven sampling in this cross-sectional study. The primary outcome in this ancillary analysis of 116 MSM was prevalence of HPV-16 and other hrHPV types. Prevalence ratios (PR) estimated the association between hrHPV and HIV-negative participants' demographics, sexual behaviour and sexually transmitted infections. Median age was 23 years and 33.6% of participants were HIV-positive. HrHPV and HPV-16 prevalence was 54.3% and 17.2%, respectively, with HPV-16 prevalence highest among HIV-positive MSM identifying as gay (36.1%) and lowest among HIV-negative MSM identifying as bisexual (2.9%). Having two or more receptive anal sex partners in the past month was associated with hrHPV (PR 3.20, 95%CI 1.69-6.07, vs. 0 partners) among HIV-negative MSM. HrHPV prevalence was high among MSM in Dar es Salaam and highest among HIV-positive MSM identifying as gay. These estimates may be used to support HPV vaccination and screening initiatives.
肛门癌主要由高危型人乳头瘤病毒（hrHPV）引起，与 HIV 感染有关，在男男性行为者（MSM）中的发病率非常高。我们评估了坦桑尼亚达累斯萨拉姆 HIV 阳性和 HIV 阴性 MSM 的肛门标本中 hrHPV 的流行情况以及与 hrHPV 相关的因素。在这项横断面研究中，我们使用应答者驱动抽样招募了 MSM。这项对 116 名 MSM 的辅助分析的主要结局是 HPV-16 和其他 hrHPV 型的流行率。患病率比（PR）用于估计 hrHPV 与 HIV 阴性参与者的人口统计学、性行为和性传播感染之间的关联。中位年龄为 23 岁，33.6%的参与者 HIV 阳性。hrHPV 和 HPV-16 的流行率分别为 54.3%和 17.2%，其中 HIV 阳性、同性恋身份的 MSM 的 HPV-16 流行率最高（36.1%），HIV 阴性、双性恋身份的 MSM 的 HPV-16 流行率最低（2.9%）。与 HIV 阴性 MSM 相比，过去一个月有两个或更多接受性肛门性伴与 hrHPV 相关（PR 3.20，95%CI 1.69-6.07，vs. 0 个性伴）。达累斯萨拉姆 MSM 中 hrHPV 的流行率很高，同性恋身份的 HIV 阳性 MSM 中最高。这些估计数可用于支持 HPV 疫苗接种和筛查计划。
