Rong Haixu, Cai Tingting, Peng Yu, Wang Xiaojuan, Lan Tianjun, Ou Zhanpeng, Qiu Ling, Li Qunxing, Zhang Lizao, Wu Fan, Lin Hsinyu, Ren Siqi, Li Zitian, Fan Song, Li Jinsong
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-sen Memorial Hospital, Guangzhou, China.
Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
Front Oncol. 2022 Mar 8;12:782058. doi: 10.3389/fonc.2022.782058. eCollection 2022.
To investigate whether TCF7 T cells constitute an important factor to improve the existing postoperative prediction model for patients with oral squamous cell carcinoma.
TCF7 T cells were detected in the tissues of 167 OSCC patients by multiplex immunofluorescence. The percentage of TCF7 T cells was transformed into a dichotomous variable, combined with the clinicopathological data for the OSCC patients, and then subjected to univariate and multivariate analyses. The derived independent predictors were then incorporated into risk models to analyze their relationship with the prognosis of patients.
The high TCF7 group had a better prognosis than the low TCF7 group (OS: <0.001; RFS: <0.001). Univariate and multivariate analyses showed that TCF7 T cells serve as an independent predictor of OSCC (univariate/multivariate analysis: <0.001). In Cox risk progression models, inclusion of the TCF7 T cell percentage improved the predictive accuracy of Grade and TNM stage (Grade-OS/RFS: <0.001; TNM-OS/RFS: <0.001; TNM+Grade-OS: <0.001, TNM+Grade-RFS: =0.004). Inclusion of the TCF7 T cell percentage improved the clinical utility.
TCF7 T cells can act as an independent predictor for postoperative OSCC patients. The inclusion of TCF7 T cells improved the predictive accuracy and clinical utility of the nomograms to different degrees.
探讨TCF7 T细胞是否构成改善口腔鳞状细胞癌患者现有术后预测模型的重要因素。
采用多重免疫荧光法检测167例口腔鳞状细胞癌患者组织中的TCF7 T细胞。将TCF7 T细胞百分比转化为二分变量，结合口腔鳞状细胞癌患者的临床病理数据，进行单因素和多因素分析。然后将得出的独立预测因子纳入风险模型，分析其与患者预后的关系。
高TCF7组的预后优于低TCF7组（总生存期：<0.001；无复发生存期：<0.001）。单因素和多因素分析表明，TCF7 T细胞是口腔鳞状细胞癌的独立预测因子（单因素/多因素分析：<0.001）。在Cox风险进展模型中，纳入TCF7 T细胞百分比可提高分级和TNM分期的预测准确性（分级-总生存期/无复发生存期：<0.001；TNM-总生存期/无复发生存期：<0.001；TNM+分级-总生存期：<0.001，TNM+分级-无复发生存期：=0.004）。纳入TCF7 T细胞百分比可提高临床实用性。
TCF7 T细胞可作为口腔鳞状细胞癌术后患者的独立预测因子。纳入TCF7 T细胞不同程度地提高了列线图的预测准确性和临床实用性。
