School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Commun Biol. 2022 Mar 28;5(1):274. doi: 10.1038/s42003-022-03215-0.
The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016-2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodelling, and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex.
青蒿素耐药疟原虫的出现和传播，首先在大湄公河次区域（GMS），现在在东非，是对全球消除疟疾目标的重大威胁。为了研究青蒿素耐药机制，对 2016-2018 年在 GMS 采集的 577 株疟原虫进行了转录组分析。确定了一个特定的与青蒿素耐药相关的转录谱，该转录谱涉及与蛋白毒性应激、宿主细胞质重塑和 REDOX 代谢相关的广泛但离散的生物功能。与青蒿素耐药相关的转录谱是由敏感寄生虫对青蒿素的初始转录反应演变而来的。这种适应反应的遗传基础可能很复杂。
