Morell A, Sidiropoulos D, Herrmann U, Christensen K K, Christensen P, Prellner K, Fey H, Skvaril F
Pediatr Res. 1986 Oct;20(10):933-6. doi: 10.1203/00006450-198610000-00005.
High doses of intravenous immunoglobulin were given to seven pregnant women between the 27th and 36th wk of gestation who were at risk for preterm delivery. Determinations of IgG subclasses and of antibodies against group B streptococcal serotypes, pneumococcal polysaccharides, and tetanus toxoid were done in maternal serum before and after intravenous IgG infusion and after delivery in cord serum. Substantial transplacental passage of the infused material could be observed in five cases where delivery occurred at the 34th wk or later. After the 36th wk of gestation, IgG subclass and antibody concentrations in cord serum were increased up to the levels in the maternal serum.
对7名妊娠27至36周有早产风险的孕妇给予大剂量静脉注射免疫球蛋白。在静脉注射免疫球蛋白前后以及分娩后采集脐血血清，测定母体血清中IgG亚类以及抗B组链球菌血清型、肺炎球菌多糖和破伤风类毒素的抗体。在5例妊娠34周或更晚分娩的病例中，可观察到注入物质的大量经胎盘转运。妊娠36周后，脐血血清中IgG亚类和抗体浓度升高至母体血清水平。
