Tian Xueying, Zhou Bin
Key Laboratory of Regenerative Medicine of Ministry of Education, Department of Developmental & Regenerative Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
J Mol Cell Cardiol. 2022 Jun;167:67-82. doi: 10.1016/j.yjmcc.2022.03.009. Epub 2022 Mar 27.
Neovascularization of the ischemic myocardium following infarction is vital for the survival of cardiomyocytes and prevention of heart failure. However, the intrinsic revascularization following ischemic injury in the heart is inadequate to restore blood flow to the infarcted myocardium. A comprehensive understanding of how coronary vasculature is constructed and what developmental pathways might be reactivated after infarction is beneficial to develop effective strategies for heart revascularization. The latest lineage tracing studies of coronary vasculature have revealed multiple developmental origins for coronary vascular endothelial cells. The development and growth of coronary vessels emanated from different cellular origins are governed by distinct regulatory mechanisms. Here, we highlight recent research advancements on cellular sources and molecular mechanisms of coronary vessel formation during heart development and regeneration, and also elaborate on how these mechanisms can be reactivated or recapitulated to facilitate therapeutic revascularization in ischemic heart disease.
心肌梗死后缺血心肌的血管新生对于心肌细胞存活及预防心力衰竭至关重要。然而，心脏缺血损伤后的内源性血管再生不足以恢复梗死心肌的血流。全面了解冠状动脉血管如何构建以及梗死后哪些发育途径可能重新激活，有助于制定有效的心脏血管再生策略。冠状动脉血管的最新谱系追踪研究揭示了冠状动脉血管内皮细胞的多个发育起源。源自不同细胞起源的冠状血管的发育和生长受不同的调节机制控制。在此，我们重点介绍心脏发育和再生过程中冠状动脉形成的细胞来源和分子机制的最新研究进展，并阐述如何重新激活或重现这些机制以促进缺血性心脏病的治疗性血管再生。
