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关于冠状动脉功能的计算见解。

Computational insights on coronary artery function.

作者信息

Mayerich David, Wythe Joshua D

机构信息

Department of Electrical and Computer Engineering, University of Houston, Houston, TX, USA.

Department of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.

出版信息

Nat Cardiovasc Res. 2022 Aug;1(8):691-693. doi: 10.1038/s44161-022-00115-8. Epub 2022 Aug 12.

DOI:10.1038/s44161-022-00115-8
PMID:37564924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10414787/
Abstract

Collateral arteries may act as natural bypasses that reduce hypoperfusion after a coronary blockage. 3D imaging of neonatal and adult mouse hearts, plus human fetal and diseased adult hearts, is now used to computationally predict flow within the heart, and understand the cardioprotective role of collateral arteries in vivo.

摘要

侧支动脉可作为天然旁路,减少冠状动脉阻塞后的灌注不足。目前,利用新生小鼠和成年小鼠心脏以及人类胎儿和患病成年心脏的三维成像,通过计算预测心脏内的血流,并了解侧支动脉在体内的心脏保护作用。

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Nat Cardiovasc Res. 2022 Aug;1(8):691-693. doi: 10.1038/s44161-022-00115-8. Epub 2022 Aug 12.
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本文引用的文献

1
Epidemiological Features of Cardiovascular Disease in Asia.亚洲心血管疾病的流行病学特征
JACC Asia. 2021 Jun 15;1(1):1-13. doi: 10.1016/j.jacasi.2021.04.007. eCollection 2021 Jun.
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Coronary vessel formation in development and regeneration: origins and mechanisms.发育和再生过程中的冠状血管形成:起源与机制
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Heart regeneration: 20 years of progress and renewed optimism.心脏再生:20 年的进展与重燃的乐观。
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European Society of Cardiology: cardiovascular disease statistics 2021.欧洲心脏病学会:2021年心血管疾病统计数据
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Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.心脏病与中风统计-2021 更新:美国心脏协会报告。
Circulation. 2021 Feb 23;143(8):e254-e743. doi: 10.1161/CIR.0000000000000950. Epub 2021 Jan 27.
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Mapping the Fine-Scale Organization and Plasticity of the Brain Vasculature.绘制大脑脉管系统的精细结构组织和可塑性图谱。
Cell. 2020 Feb 20;180(4):780-795.e25. doi: 10.1016/j.cell.2020.01.028. Epub 2020 Feb 13.
7
A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration.一种独特的侧支动脉发育方案促进新生儿心脏再生。
Cell. 2019 Feb 21;176(5):1128-1142.e18. doi: 10.1016/j.cell.2018.12.023. Epub 2019 Jan 24.
8
Cardiomyocyte renewal in the human heart: insights from the fall-out.人心肌细胞的再生:来自放射性坠尘的启示。
Eur Heart J. 2017 Aug 7;38(30):2333-2342. doi: 10.1093/eurheartj/ehx343.
9
Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart.遗传谱系追踪揭示动脉生成是小鼠心脏侧支生长的主要机制。
Cardiovasc Res. 2016 Mar 1;109(3):419-30. doi: 10.1093/cvr/cvw005. Epub 2016 Jan 13.
10
De-novo collateral formation following acute myocardial infarction: Dependence on CCR2⁺ bone marrow cells.急性心肌梗死后的新生侧支形成:对CCR2⁺骨髓细胞的依赖性。
J Mol Cell Cardiol. 2015 Oct;87:4-16. doi: 10.1016/j.yjmcc.2015.07.020. Epub 2015 Aug 4.