Gkougka Dionysia, Mitropoulos Konstantinos, Tzanakaki Georgia, Panagouli Eleni, Psaltopoulou Theodora, Thomaidis Loretta, Tsolia Maria, Sergentanis Theodoros N, Tsitsika Artemis
MSc Program "Strategies of Developmental and Adolescent Health", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Department of Public Health Policy, School of Public Health, University of West Attica, Athens, Greece.
Pediatr Res. 2022 Dec;92(6):1507-1519. doi: 10.1038/s41390-022-02027-6. Epub 2022 Mar 30.
This systematic review aims to examine the associations between features of gut microbiome and Attention Deficit/Hyperactivity Disorder (ADHD) risk or severity in children, adolescents and young adults.
Eligible studies were identified in PubMed and Google Scholar databases until December 31, 2020.
The search identified a total of 1197 items, of which 11 were included in this systematic review. The findings regarding alpha, beta diversity, bacterial phyla, orders and families were inconclusive. At the genus level an increased abundance of Odoribacter (two studies) and Eggerthella (two studies) was found in ADHD; on the contrary, decreased abundance of Faecalibacterium (three studies) was noted, whereas one study suggested its inverse association with ADHD severity and hyperactivity. One study indicated that Bacteroides species also correlated with levels of hyperactivity and impulsivity. At the species level, a lower abundance of Faecalibacterium prausnitzii, but higher of Odoribacter splanchnicus and Bacteroides uniformis was reported.
This systematic review highlights associations between gut microbiome features and ADHD. Potential mechanisms differ by microorganism and include effects on neurotransmitter production, dopamine metabolism, modulation of inflammation and neurodevelopment through the release of cytokines.
The existence of correlations between features of gut microbiome and ADHD manifestation or its severity in children, adolescents and young adults. Associations between gut microbiome features and ADHD are highlighted. Potential mechanisms seem to differ by microorganism and include effects on neurotransmitter production, dopamine metabolism, modulation of inflammation and neurodevelopment through the release of cytokines. As correlations between gut microbiome features and ADHD seem to exist, additional studies are needed for further investigation.
本系统评价旨在研究儿童、青少年和青年人群肠道微生物群特征与注意力缺陷多动障碍（ADHD）风险或严重程度之间的关联。
在PubMed和谷歌学术数据库中检索截至2020年12月31日的相关合格研究。
检索共识别出1197条记录，其中11条纳入本系统评价。关于α多样性、β多样性、细菌门、纲和科的研究结果尚无定论。在属水平上，ADHD患者中发现Odoribacter（两项研究）和Eggerthella（两项研究）丰度增加；相反，Faecalibacterium丰度降低（三项研究），而一项研究表明其与ADHD严重程度和多动呈负相关。一项研究表明拟杆菌属物种也与多动和冲动水平相关。在种水平上，报告显示普拉梭菌丰度较低，但内脏Odoribacter和单形拟杆菌丰度较高。
本系统评价强调了肠道微生物群特征与ADHD之间的关联。潜在机制因微生物而异，包括对神经递质产生、多巴胺代谢、炎症调节以及通过细胞因子释放对神经发育的影响。
肠道微生物群特征与儿童、青少年和青年人群ADHD表现或严重程度之间存在相关性。强调了肠道微生物群特征与ADHD之间的关联。潜在机制似乎因微生物而异，包括对神经递质产生、多巴胺代谢、炎症调节以及通过细胞因子释放对神经发育的影响。由于肠道微生物群特征与ADHD之间似乎存在相关性，因此需要进一步研究。
