Jiang Hai-Yin, Zhou Yuan-Yue, Zhou Guo-Ling, Li Yu-Chuan, Yuan Jing, Li Xiao-He, Ruan Bing
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
Department of Child Psychiatry, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang, 310013, China.
Behav Brain Res. 2018 Jul 16;347:408-413. doi: 10.1016/j.bbr.2018.03.036. Epub 2018 Mar 23.
Although increasing evidence suggests a role for the gut microbiota in neurodevelopment, the actual structure and composition of microbiota in children with attention-deficit/hyperactivity disorder (ADHD) remain unclear.
Thus, the present study aimed to define the characteristics of gut microbiota in treatment-naive children with ADHD and to assess their relationship with the severity of ADHD symptoms. High-throughput pyrosequencing was used to investigate the microbiota composition in fecal matter from 51 children with ADHD and 32 healthy controls (HC).
An operational taxonomical unit (OTU)-level analysis revealed a significant decrease in the fractional representation of Faecalibacterium in children with ADHD compared to HC. In individuals with ADHD, the abundance of Faecalibacterium was negatively associated with parental reports of ADHD symptoms. However, there was no significant difference in alpha diversity between the ADHD and control groups.
This present findings support the involvement of microbiota alteration in psychiatric diseases and Faecalibacterium may represent a potential novel marker of gut microbiota in ADHD. Future studies are needed to validate these findings and to elucidate the temporal and causal relationships between these variables.
尽管越来越多的证据表明肠道微生物群在神经发育中发挥作用，但注意力缺陷多动障碍（ADHD）患儿微生物群的实际结构和组成仍不清楚。
因此，本研究旨在确定未经治疗的ADHD患儿肠道微生物群的特征，并评估它们与ADHD症状严重程度的关系。采用高通量焦磷酸测序技术研究了51例ADHD患儿和32例健康对照（HC）粪便中的微生物群组成。
在操作分类单元（OTU）水平上的分析显示，与HC相比，ADHD患儿中粪杆菌的相对丰度显著降低。在ADHD个体中，粪杆菌的丰度与父母报告的ADHD症状呈负相关。然而，ADHD组和对照组之间的α多样性没有显著差异。
本研究结果支持微生物群改变与精神疾病有关，粪杆菌可能是ADHD肠道微生物群的一个潜在新标志物。未来需要进一步研究来验证这些发现，并阐明这些变量之间的时间和因果关系。
