• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用 18F-FDG PET 成像比较小鼠的短暂性和永久性左前降支结扎。

Comparison of transient and permanent LAD ligation in mice using 18F-FDG PET imaging.

机构信息

Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität, Marchioninistrasse 15, 81377, Munich, Germany.

DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 80802, Munich, Germany.

出版信息

Ann Nucl Med. 2022 Jun;36(6):533-543. doi: 10.1007/s12149-022-01734-8. Epub 2022 Mar 30.

DOI:10.1007/s12149-022-01734-8
PMID:35355159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9132804/
Abstract

OBJECTIVE

Animal models for myocardial injuries represent important cornerstones in cardiovascular research to monitor the pathological processes and therapeutic approaches. We investigated the association of 18F-FDG derived left ventricular metabolic volume (LVMV), defect area and cardiac function in mice after permanent or transient ligation of the left anterior descending artery (LAD).

METHODS

Serial non-invasive ECG-gated 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (18F-FDG PET) after permanent or transient LAD ligation enabled a longitudinal in vivo correlation of 18F-FDG derived left ventricular metabolic volume to functional parameters and myocardial defect.

RESULTS

The LVMV shows a more prominent drop after permanent than transient LAD ligation and recovers after 30 days. The loss of LVMV correlates with the defect area assessed by QPS software. Cardiac function parameters (e.g., EDV, ESV, SV) by the QGS software positively correlate with LVMV after permanent and transient LAD ligation.

CONCLUSIONS

This study provides novel insight into 18F-FDG derived LVMV after permanent and transient LAD ligation by longitudinal in 18F-FDG PET imaging and underlines the associations of the FDG derived parameter and cardiac function.

摘要

目的

心肌损伤的动物模型是心血管研究中的重要基石，可用于监测病理过程和治疗方法。我们研究了左前降支（LAD）永久性或暂时性结扎后，18F-FDG 衍生的左心室代谢容积（LVMV）、缺陷面积和心功能之间的关系。

方法

永久性或暂时性 LAD 结扎后进行连续的非侵入性 ECG 门控 2-脱氧-2-[18F]氟-D-葡萄糖正电子发射断层扫描（18F-FDG PET），使 18F-FDG 衍生的左心室代谢容积与功能参数和心肌缺陷的纵向体内相关性成为可能。

结果

LVMV 在永久性 LAD 结扎后比暂时性 LAD 结扎后下降更为明显，30 天后恢复。LVMV 的损失与 QPS 软件评估的缺陷面积相关。QGS 软件评估的心脏功能参数（如 EDV、ESV、SV）与永久性和暂时性 LAD 结扎后的 LVMV 呈正相关。

结论

本研究通过 18F-FDG PET 成像的纵向研究，提供了永久性和暂时性 LAD 结扎后 18F-FDG 衍生的 LVMV 的新见解，并强调了 FDG 衍生参数与心功能之间的关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16da/9132804/70d6a435db3e/12149_2022_1734_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16da/9132804/a019360981e3/12149_2022_1734_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16da/9132804/b042a8a2f308/12149_2022_1734_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16da/9132804/247055aa265e/12149_2022_1734_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16da/9132804/59924eb3638a/12149_2022_1734_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16da/9132804/70d6a435db3e/12149_2022_1734_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16da/9132804/a019360981e3/12149_2022_1734_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16da/9132804/b042a8a2f308/12149_2022_1734_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16da/9132804/247055aa265e/12149_2022_1734_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16da/9132804/59924eb3638a/12149_2022_1734_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16da/9132804/70d6a435db3e/12149_2022_1734_Fig5_HTML.jpg

相似文献

1
Comparison of transient and permanent LAD ligation in mice using 18F-FDG PET imaging.使用 18F-FDG PET 成像比较小鼠的短暂性和永久性左前降支结扎。
Ann Nucl Med. 2022 Jun;36(6):533-543. doi: 10.1007/s12149-022-01734-8. Epub 2022 Mar 30.
2
Cardiac 18F-FDG Positron Emission Tomography: An Accurate Tool to Monitor Metabolic and Functional Alterations in Murine Myocardial Infarction.心脏18F-FDG正电子发射断层扫描：监测小鼠心肌梗死代谢和功能改变的精确工具。
Front Cardiovasc Med. 2021 May 25;8:656742. doi: 10.3389/fcvm.2021.656742. eCollection 2021.
3
18F-FDG PET-Based Imaging of Myocardial Inflammation Predicts a Functional Outcome Following Transplantation of mESC-Derived Cardiac Induced Cells in a Mouse Model of Myocardial Infarction.18F-FDG PET 心肌炎症显像预测心肌梗死后 mESC 衍生的心脏诱导细胞移植后心功能结局
Cells. 2019 Dec 11;8(12):1613. doi: 10.3390/cells8121613.
4
Detection of cardiac apoptosis by [F]ML-10 in a mouse model of permanent LAD ligation.通过 [F]ML-10 在永久性 LAD 结扎小鼠模型中检测心脏细胞凋亡。
Mol Imaging Biol. 2022 Aug;24(4):666-674. doi: 10.1007/s11307-022-01718-0. Epub 2022 Mar 29.
5
Detection of apoptosis by [F]ML-10 after cardiac ischemia-reperfusion injury in mice.通过 [F]ML-10 检测小鼠心肌缺血再灌注损伤后的细胞凋亡。
Ann Nucl Med. 2023 Jan;37(1):34-43. doi: 10.1007/s12149-022-01801-0. Epub 2022 Oct 28.
6
Gated cardiac 13N-NH3 PET for assessment of left ventricular volumes, mass, and ejection fraction: comparison with electrocardiography-gated 18F-FDG PET.门控心脏13N-氨正电子发射断层显像用于评估左心室容积、质量和射血分数：与心电图门控18F-氟脱氧葡萄糖正电子发射断层显像的比较
J Nucl Med. 2005 Dec;46(12):2009-13.
7
Quantification of left ventricular volumes and ejection fraction in mice using PET, compared with MRI.使用正电子发射断层扫描（PET）对小鼠左心室容积和射血分数进行定量分析，并与磁共振成像（MRI）进行比较。
J Nucl Med. 2009 Jan;50(1):132-8. doi: 10.2967/jnumed.108.056051. Epub 2008 Dec 17.
8
Monitoring of Cardiac Remodeling in a Mouse Model of Pressure-Overload Left Ventricular Hypertrophy with [F]FDG MicroPET.使用 [F]FDG 微 PET 监测压力超负荷左心室肥厚小鼠模型中的心脏重构。
Mol Imaging Biol. 2018 Apr;20(2):268-274. doi: 10.1007/s11307-017-1114-6.
9
Comparison of metabolic and functional parameters using cardiac 18F-FDG-PET in early to mid-adulthood male and female mice.使用心脏18F-FDG-PET对成年早期至中期雄性和雌性小鼠的代谢和功能参数进行比较。
EJNMMI Res. 2021 Jan 19;11(1):7. doi: 10.1186/s13550-021-00748-z.
10
Gated F-18 FDG PET for assessment of left ventricular volumes and ejection fraction using QGS and 4D-MSPECT in patients with heart failure: a comparison with cardiac MRI.门控 F-18 FDG PET 用于评估心力衰竭患者左心室容积和射血分数：与心脏 MRI 的比较。
PLoS One. 2014 Jan 3;9(1):e80227. doi: 10.1371/journal.pone.0080227. eCollection 2014.

引用本文的文献

1
Effects and mechanisms of the myocardial microenvironment on cardiomyocyte proliferation and regeneration.心肌微环境对心肌细胞增殖和再生的影响及机制。
Front Cell Dev Biol. 2024 Jul 10;12:1429020. doi: 10.3389/fcell.2024.1429020. eCollection 2024.
2
The assessment of left ventricular volume and function in gated small animal F-FDG PET/CT imaging: a comparative study of three commercially available software tools.门控小动物F-FDG PET/CT成像中左心室容积和功能的评估：三种商用软件工具的比较研究
EJNMMI Res. 2023 Aug 12;13(1):75. doi: 10.1186/s13550-023-01026-w.
3
Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers.

本文引用的文献

1
Expedient assessment of post-infarct remodeling by native cardiac magnetic resonance imaging in mice.通过小鼠的心脏磁共振成像对心肌梗死后重构进行即时评估。
Sci Rep. 2021 Jun 2;11(1):11625. doi: 10.1038/s41598-021-91096-4.
2
The Role of Immune Cells in Cardiac Remodeling After Myocardial Infarction.免疫细胞在心肌梗死后心肌重构中的作用。
J Cardiovasc Pharmacol. 2020 Oct;76(4):407-413. doi: 10.1097/FJC.0000000000000876.
3
Myocardial ischaemia-reperfusion injury and cardioprotection in perspective.心肌缺血再灌注损伤及心肌保护的展望。
心血管疾病研究中使用动物模型和正电子发射断层扫描放射性示踪剂的最新进展。
Int J Mol Sci. 2022 Dec 26;24(1):353. doi: 10.3390/ijms24010353.
4
Quo Vadis? Immunodynamics of Myeloid Cells after Myocardial Infarction.路在何方？心肌梗死后髓系细胞的免疫动力学
Int J Mol Sci. 2022 Dec 13;23(24):15814. doi: 10.3390/ijms232415814.
Nat Rev Cardiol. 2020 Dec;17(12):773-789. doi: 10.1038/s41569-020-0403-y. Epub 2020 Jul 3.
4
F-FDG PET-Based Imaging of Myocardial Inflammation Following Acute Myocardial Infarction in a Mouse Model.基于 F-FDG PET 的急性心肌梗死后小鼠模型心肌炎症成像。
Int J Mol Sci. 2020 May 8;21(9):3340. doi: 10.3390/ijms21093340.
5
Cardiac monocytes and macrophages after myocardial infarction.心肌梗死后的心脏单核细胞和巨噬细胞。
Cardiovasc Res. 2020 May 1;116(6):1101-1112. doi: 10.1093/cvr/cvz336.
6
18F-FDG PET-Based Imaging of Myocardial Inflammation Predicts a Functional Outcome Following Transplantation of mESC-Derived Cardiac Induced Cells in a Mouse Model of Myocardial Infarction.18F-FDG PET 心肌炎症显像预测心肌梗死后 mESC 衍生的心脏诱导细胞移植后心功能结局
Cells. 2019 Dec 11;8(12):1613. doi: 10.3390/cells8121613.
7
2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes.2019年欧洲心脏病学会慢性冠状动脉综合征诊断和管理指南
Eur Heart J. 2020 Jan 14;41(3):407-477. doi: 10.1093/eurheartj/ehz425.
8
Cardioimmunology: the immune system in cardiac homeostasis and disease.心脏免疫学：心脏稳态和疾病中的免疫系统。
Nat Rev Immunol. 2018 Dec;18(12):733-744. doi: 10.1038/s41577-018-0065-8.
9
2018 ESC/EACTS Guidelines on myocardial revascularization.2018年欧洲心脏病学会/欧洲心胸外科学会心肌血运重建指南。
Eur Heart J. 2019 Jan 7;40(2):87-165. doi: 10.1093/eurheartj/ehy394.
10
Quantification of myocardial infarct area based on T relaxation time maps - comparison with cardiovascular magnetic resonance late gadolinium enhancement, T and T in vivo.基于 T 弛豫时间图的心肌梗死面积定量 - 与心血管磁共振晚期钆增强、T 及体内 T 的比较。
J Cardiovasc Magn Reson. 2018 Jun 7;20(1):34. doi: 10.1186/s12968-018-0463-x.