Department of Gastrointestinal Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong 519000, China.
Dis Markers. 2022 Mar 20;2022:7913025. doi: 10.1155/2022/7913025. eCollection 2022.
To investigate the application value of combined detection of neutrophil-lymphocyte ratio (NLR), prognostic nutrition index (PNI), D-dimer (D-D), CD3 T lymphocytes (CD3 T), and carcinoembryonic antigen (CEA) in colorectal cancer screening.
The study cohort comprised 187 colorectal cancer patients and 100 mixed hemorrhoids patients as controls from January 2019 to August 2021 at the Fifth Affiliated Hospital of Sun Yat-sen University. Comparing the levels of NLR, PNI, D-D, CD3 T, and CEA between the two groups of subjects, drawing receiver operating characteristic (ROC) curve evaluates the efficacy of single and combined detection for colorectal cancer screening.
Compared with the control group, the levels of NLR, D-D, and CEA in the colorectal cancer group were significantly increased, while the levels of PNI and CD3 T were significantly decreased ( < 0.05). ROC curve analysis showed that the combined detection of NLR, PNI, D-D, CD3 T, and CEA for colorectal cancer screening had an AUC of 0.943, a sensitivity of 84.49%, a specificity of 91.00%, and a Youden index of 0.75, and its screening efficacy was significantly superior to that of a single detection ( < 0.001).
The combined detection of NLR, PNI, D-D, CD3 T, and CEA has a high clinical application value for colorectal cancer and can provide a reference for early screening and auxiliary diagnosis of colorectal cancer.
探讨中性粒细胞-淋巴细胞比值（NLR）、预后营养指数（PNI）、D-二聚体（D-D）、CD3T 淋巴细胞（CD3T）和癌胚抗原（CEA）联合检测在结直肠癌筛查中的应用价值。
选取 2019 年 1 月至 2021 年 8 月中山大学附属第五医院收治的 187 例结直肠癌患者和 100 例混合痔患者为研究对象。比较两组受试者 NLR、PNI、D-D、CD3T 和 CEA 水平，绘制受试者工作特征（ROC）曲线评估单项及联合检测对结直肠癌筛查的效能。
与对照组相比，结直肠癌组 NLR、D-D 和 CEA 水平明显升高，PNI 和 CD3T 水平明显降低（<0.05）。ROC 曲线分析显示，NLR、PNI、D-D、CD3T 和 CEA 联合检测对结直肠癌筛查的 AUC 为 0.943，灵敏度为 84.49%，特异度为 91.00%，Youden 指数为 0.75，其筛查效能明显优于单项检测（<0.001）。
NLR、PNI、D-D、CD3T 和 CEA 联合检测对结直肠癌具有较高的临床应用价值，可为结直肠癌的早期筛查和辅助诊断提供参考。
