Park Kyung-Shin, Nickerson Brett S
Kinesiology, Texas A&M International University, Laredo, TX, USA.
J Exerc Rehabil. 2022 Feb 24;18(1):43-49. doi: 10.12965/jer.2142724.352. eCollection 2022 Feb.
The purpose of this study was to investigate the effects of a 4-week moderate-intensity aerobic exercise on changes of body composition and markers of inflammation and oxidative stress independent from weight loss in middle-aged obese females. Thity-five obese females were randomly assigned to either an exercise (EX, N=16) or control (CON, N=19) group. The EX performed moderate intensity aerobic exercise on the treadmill for 60 min at 55% of maximal oxygen consumption (VO) for 4 weeks (3 days/wk). Body composition measurement with dual-energy x-ray absorptiometry and blood collection were conducted before and after the 4-weeks intervention. Blood samples were used to measure levels of tumor necrosis factor-alpha (TNF-α), C-reactive protein, adiponectin, total antioxidant status (TAS), and 8-hydroxydeoxyguanosine. Four weeks of aerobic exercise intervention significantly increased VO in EX (<0.001). EX also observed a decrease in TNF-α (=0.033) and an increase in TAS (=0.028) without changes in body weight and fat mass after 4 weeks of aerobic exercise training. No changes were observed in CON after the intervention. Results of this study indicate that moderate aerobic exercises may contribute, at least a part, to reductions of inflammation and oxidative stress independently from fat loss. Therefore, it may reduce risks of obesity-associated disorders in middle-aged obese females.
本研究的目的是调查为期4周的中等强度有氧运动对中年肥胖女性身体成分变化以及炎症和氧化应激标志物的影响，且该影响独立于体重减轻。35名肥胖女性被随机分为运动组（EX，N = 16）或对照组（CON，N = 19）。运动组在跑步机上以最大耗氧量（VO）的55%进行60分钟中等强度有氧运动，持续4周（每周3天）。在4周干预前后进行双能X线吸收法测量身体成分和采血。采集血样用于测量肿瘤坏死因子-α（TNF-α）、C反应蛋白、脂联素、总抗氧化状态（TAS）和8-羟基脱氧鸟苷水平。4周的有氧运动干预使运动组的VO显著增加（<0.001）。有氧运动训练4周后，运动组还观察到TNF-α降低（=0.033）和TAS增加（=0.028），而体重和脂肪量无变化。干预后对照组未观察到变化。本研究结果表明，中等强度有氧运动可能至少部分有助于独立于脂肪减少来减轻炎症和氧化应激。因此，它可能降低中年肥胖女性肥胖相关疾病的风险。
