Muñoz-Espin T, López-Parés P, Espejo-Arenas E, Font-Creus B, Martinez-Vila I, Travería-Casanova J, Segura-Porta F, Bella-Cueto F
Arch Dis Child. 1986 Oct;61(10):1027-9. doi: 10.1136/adc.61.10.1027.
Eighty one children aged between 1 and 13 years participated in a randomised comparative trial of tetracycline hydrochloride and erythromycin stearate for treatment of Mediterranean spotted fever. Both therapeutic regimens proved effective, but in patients treated with tetracycline both clinical symptoms and fever disappeared significantly more quickly. Likewise, when those patients who began treatment within the first 72 hours of illness are considered the febrile period had a significantly shorter duration in the group treated with tetracycline. One patient was switched to tetracycline because there was no improvement of clinical manifestations, with persistence of fever, myalgias, and prostration, after receiving eight days of treatment with erythromycin. These results suggest that tetracyclines are superior to erythromycin in the treatment of Mediterranean spotted fever.
81名年龄在1至13岁之间的儿童参与了一项关于盐酸四环素和硬脂酸红霉素治疗地中海斑疹热的随机对照试验。两种治疗方案均被证明有效，但接受四环素治疗的患者临床症状和发热消失得明显更快。同样，当考虑那些在发病后72小时内开始治疗的患者时，四环素治疗组的发热期明显更短。一名患者在接受红霉素治疗8天后，临床表现没有改善，仍持续发热、肌痛和极度虚弱，因此改用四环素治疗。这些结果表明，在治疗地中海斑疹热方面，四环素优于红霉素。
