Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.
Department of Obstetrics and Gynecology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Acta Paediatr. 2022 Jul;111(7):1427-1434. doi: 10.1111/apa.16346. Epub 2022 Apr 5.
We investigated associations between newborn body composition and anthropometry and body composition at 3 years in Danish children born from obese mothers.
Analyses are based on data from the observational cohort study SKOT II (SKOT; small children's diet and well-being (Danish)). Body composition at birth and at 3 years was assessed by dual-energy X-ray absorptiometry (DXA) scans and bioelectrical impedance analysis (BIA), respectively. Multiple linear regression models were applied to determine associations between newborn body composition and anthropometry and body composition at 3 years.
Birthweight z-score (BWZ) was positively associated with fat-free mass (FFM), height, fat-free mass index (FFMI), fat mass (FM) and fat mass index (FMI) at 3 years. Newborn FFM was positively associated with FFM, height, FFMI and FM at 3 years, and positive trends were seen between newborn FM and FM and FMI at 3 years.
We showed that infants born with a higher BWZ go on to be taller at 3 years. They also grow to be heavier, to which FM and FFM both contribute, independently of linear growth. Additionally, it seems that FFM tracks into early childhood, thus supporting intrauterine programming of later health.
我们研究了肥胖母亲所生丹麦儿童的新生儿体成分和人体测量学与 3 岁时体成分之间的关联。
分析基于观察性队列研究 SKOT II（SKOT；儿童饮食与健康（丹麦））的数据。通过双能 X 射线吸收法（DXA）扫描和生物电阻抗分析（BIA）分别评估出生时和 3 岁时的体成分。应用多元线性回归模型确定新生儿体成分和人体测量学与 3 岁时体成分之间的关联。
出生体重 z 评分（BWZ）与 3 岁时的去脂体重（FFM）、身高、FFMI、脂肪量（FM）和 FMI 呈正相关。新生儿 FFM 与 3 岁时的 FFM、身高、FFMI 和 FM 呈正相关，新生儿 FM 与 3 岁时的 FM 和 FMI 呈正相关趋势。
我们表明，出生时 BWZ 较高的婴儿在 3 岁时长得更高。他们也会变得更重，这与 FM 和 FFM 的增长有关，而与线性生长无关。此外，FFM 似乎会追踪到幼儿期，从而支持宫内编程对后期健康的影响。
