Gürkaş Esra, Dünya Betül, Köken Özlem Y, Demirdağ Tuğba B, Yilmaz Deniz, Özyürek Hamit, Kurt Ayşegül N Ç
Department of Pediatric Neurology, Ankara City Hospital, Children's' Hospital, Ankara, Turkey.
Department of Pediatric Infectious Disease, Gazi University, Ankara, Turkey.
Ann Indian Acad Neurol. 2021 Nov-Dec;24(6):891-895. doi: 10.4103/aian.AIAN_225_21. Epub 2021 Dec 8.
The data related to the neurologic manifestations of coronavirus disease 2019 (COVID-19) in children are limited. The frequency of the neurologic manifestations and the risk factors in the development of these symptoms are not clear.
We aimed to determine the exact frequency of the neurological symptoms in pediatric patients with confirmed COVID-19 and to identify the risk factors for the development of neurological manifestations.
We included pediatric Covid-19 patients admitted to the Children's Hospital of Ankara City Hospital between March 22 and June 1, 2020. Neurological findings were questioned by interviewing the patients and their families and detailed neurologic examinations were performed within protection measures.
A total of 312 pediatric patients with the diagnosis of COVID-19 were enrolled in the study. Sixty-six participants (21.15%) showed neurologic symptoms during COVID-19. Headache was the most common neurologic symptom and present in 14% (: 44) of the cases. The other neurologic symptoms were myalgia (: 30, 9.6%), anosmia/hyposmia (: 6, 1.9%), ageusia (: 2, 0.6%), and vertigo (: 1, 0.3%). Neutrophil-to-lymphocyte ratio (NLR) ( = 0.002) and platelet-to-lymphocyte ratio (PLR) ( = 0.001) were significantly elevated in patients with neurological symptoms when compared to the patients without the symptoms.
Physicians should be alert to the neurologic involvement of COVID-19 disease in children. NLR and PLR ratios could have a predictive value for the development of neurological manifestations.
关于2019冠状病毒病（COVID-19）儿童神经表现的数据有限。神经表现的频率以及这些症状发生发展的危险因素尚不清楚。
我们旨在确定确诊为COVID-19的儿科患者神经症状的确切频率，并确定神经表现发生发展的危险因素。
我们纳入了2020年3月22日至6月1日期间入住安卡拉市立医院儿童医院的儿科COVID-19患者。通过与患者及其家属面谈询问神经学发现，并在采取保护措施的情况下进行详细的神经学检查。
共有312例诊断为COVID-19的儿科患者纳入本研究。66名参与者（21.15%）在感染COVID-19期间出现神经症状。头痛是最常见的神经症状，14%（n = 44）的病例出现头痛。其他神经症状包括肌痛（n = 30，9.6%）、嗅觉减退/嗅觉丧失（n = 6，1.9%）、味觉减退（n = 2，0.6%）和眩晕（n = 1，0.3%）。与无症状患者相比，有神经症状的患者中性粒细胞与淋巴细胞比值（NLR）（P = 0.002）和血小板与淋巴细胞比值（PLR）（P = 0.001）显著升高。
医生应警惕COVID-19疾病在儿童中的神经受累情况。NLR和PLR比值可能对神经表现的发生发展具有预测价值。
