Department of Endocrinology, the First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
Department of Endocrinology, the Eighth Medical Center of People's Liberation Army (PLA) General Hospital, Beijing, China.
Front Endocrinol (Lausanne). 2022 Mar 11;13:817620. doi: 10.3389/fendo.2022.817620. eCollection 2022.
Hundreds of research and review articles concerning genome-wide association study (GWAS) in diabetes have been published in the last two decades. We aimed to evaluate the hotspots and future trends in GWAS in diabetes research through bibliometric analysis. Accordingly, 567 research and review articles published between 2001 and 2021 were included. A rising trend was noted in the annual number of publications and citations on GWAS in diabetes during this period. Harvard University and Harvard Medical School have played leading roles in genome research. Hotspot analyses indicated that DNA methylation and genetic variation, especially in type 2 diabetes mellitus, are likely to remain the research hotspots. Moreover, the identification of genetic phenotypes associated with adiposity, metabolic memory, pancreatic islet, and inflammation is the leading trend in this research field. Through this review, we provide predictions on the main research trends in the future so as to shed light on new directions and ideas for further investigations on the genetic etiology of diabetes for its prevention and treatment.
在过去的二十年中，已经发表了数百篇关于糖尿病全基因组关联研究（GWAS）的研究和综述文章。我们旨在通过文献计量分析评估糖尿病 GWAS 研究中的热点和未来趋势。因此，纳入了 2001 年至 2021 年期间发表的 567 篇研究和综述文章。在此期间，糖尿病 GWAS 的年度出版物数量和引文数量呈上升趋势。哈佛大学和哈佛医学院在基因组研究中发挥了主导作用。热点分析表明，DNA 甲基化和遗传变异，特别是 2 型糖尿病，可能仍然是研究热点。此外，鉴定与肥胖、代谢记忆、胰岛和炎症相关的遗传表型是该研究领域的主要趋势。通过这项综述，我们对未来的主要研究趋势进行了预测，以期为糖尿病遗传病因学的预防和治疗提供新的方向和思路。
