Institute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, Wuhan, China.
Front Cell Infect Microbiol. 2022 Mar 14;12:789063. doi: 10.3389/fcimb.2022.789063. eCollection 2022.
Probiotics play an important role against infectious pathogens their effects on the epithelium, the production of antimicrobial compounds, and competitive exclusion. Administration of probiotic supplements may reduce the risk of infectious diseases and the use of antibiotics, hence contributing to a reduction or a delay of the development of multi-resistant bacteria. Infection is a constant concern for people who experience recurrent infections, and antibiotic treatment usually fails due to antibiotic resistance. Therefore, an infection can lead to severe illness and hospitalization if left untreated. A growing number of studies have demonstrated promising results for a variety of probiotic strains used to prevent or treat acute and recurrent infectious diseases, but additional standardized clinical research is needed.
益生菌在对抗感染性病原体方面发挥着重要作用，其作用机制包括对上皮细胞的影响、抗菌化合物的产生和竞争性排斥。益生菌补充剂的使用可能会降低感染性疾病和抗生素使用的风险，从而有助于减少或延缓多药耐药菌的产生。对于经常发生感染的人来说，感染是一个持续存在的问题，而且由于抗生素耐药性，抗生素治疗通常会失败。因此，如果不进行治疗，感染可能会导致严重疾病和住院治疗。越来越多的研究表明，多种益生菌菌株在预防和治疗急性和复发性传染病方面具有良好的效果，但需要进行更多标准化的临床研究。
