Fabiani Ester, Strand Martin Frank, Lindberg Morten, Goswami Nandu, Fredriksen Per Morten
University Medical Centre Ljubljana, Slovenia.
Alma Mater Europaea-ECM Maribor, Maribor, Slovenia.
Glob Pediatr Health. 2022 Mar 23;9:2333794X221079558. doi: 10.1177/2333794X221079558. eCollection 2022.
Early stages of atherosclerosis may develop in childhood due to hyperlipidemia. The aims are to investigate the prevalence of familiar hypercholesterolemia in 6 to 12-year-old children and to study the deviation in cholesterol measures. Anthropometric data and venous blood were collected from children participating in the Health Oriented Pedagogical Project (HOPP). Out of 18 children with TC > 6.0 mmol/L, 15 were tested genetically and none diagnosed with FH. The prevalence of TC > 6.0 mmol/L declined from 1.3% in 2015 to 0.5% in 2016. The mean TC was 4.30 mmol/L both years, which is lower than in earlier studies. Usage of a single TC measurement and a threshold of TC > 6.0 mmol/L in screening children for FH, may not be a good screening strategy. While lipid values have a good reliability across 2 measurements, there are variations in individual TC levels across 1 year.
由于高脂血症，动脉粥样硬化的早期阶段可能在儿童期就会出现。目的是调查6至12岁儿童家族性高胆固醇血症的患病率，并研究胆固醇测量值的偏差。从参与健康导向教育项目（HOPP）的儿童中收集人体测量数据和静脉血。在18名总胆固醇（TC）>6.0 mmol/L的儿童中，15名接受了基因检测，无一被诊断为家族性高胆固醇血症（FH）。TC>6.0 mmol/L的患病率从2015年的1.3%降至2016年的0.5%。这两年的平均TC均为4.30 mmol/L，低于早期研究。在筛查儿童FH时使用单次TC测量以及TC>6.0 mmol/L的阈值，可能不是一个好的筛查策略。虽然脂质值在两次测量之间具有良好的可靠性，但个体TC水平在1年内存在差异。
