Mehringer Johannes, Navarro Juan Antonio, Touraud Didier, Schneuwly Stephan, Kunz Werner
Institute of Physical and Theoretical Chemistry, University of Regensburg Germany
INCLIVA Biomedical Research Institute Valencia Spain.
RSC Chem Biol. 2022 Jan 4;3(2):250-260. doi: 10.1039/d1cb00220a. eCollection 2022 Feb 9.
The stability of proteins in solution poses a great challenge for both technical applications and molecular biology, including neurodegenerative diseases. In this work, a phosphorylated resveratrol material was examined for its anti-aggregation properties and . Here, an anti-fibrillation effect could be measured for amyloid beta and human insulin and general anti-aggregation properties for crude chicken egg white in solution. Using a drosophila fly model for the overexpression of amyloid beta protein, changes in physiological protein aggregation and improved locomotor abilities could be observed in the presence of dietary phosphorylated resveratrol.
蛋白质在溶液中的稳定性对技术应用和分子生物学（包括神经退行性疾病）都构成了巨大挑战。在这项工作中，研究了一种磷酸化白藜芦醇材料的抗聚集特性。在此，可以检测到β-淀粉样蛋白和人胰岛素的抗纤维化作用，以及溶液中粗制鸡蛋白的一般抗聚集特性。使用果蝇模型来过度表达β-淀粉样蛋白，在饮食中添加磷酸化白藜芦醇的情况下，可以观察到生理蛋白质聚集的变化以及运动能力的改善。
