Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA; email:
Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
Annu Rev Genomics Hum Genet. 2022 Aug 31;23:613-625. doi: 10.1146/annurev-genom-112921-022635. Epub 2022 Apr 1.
Since the completion of the Human Genome Project, considerable progress has been made in translating knowledge about the genetic basis of disease risk and treatment response into clinical services and public health interventions that have greater precision. It is anticipated that more precision approaches to early detection, prevention, and treatment will be developed and will enhance equity in healthcare and outcomes among disparity populations. Reduced access to genomic medicine research, clinical services, and public health interventions has the potential to exacerbate disparities in genomic medicine. The purpose of this article is to describe these challenges to equity in genomic medicine and identify opportunities and future directions for addressing these issues. Efforts are needed to enhance access to genomic medicine research, clinical services, and public health interventions, and additional research that examines the clinical utility of precision medicine among disparity populations should be prioritized to ensure equity in genomic medicine.
自人类基因组计划完成以来，在将疾病风险和治疗反应的遗传基础知识转化为更精准的临床服务和公共卫生干预措施方面已经取得了相当大的进展。预计将开发出更多针对早期检测、预防和治疗的精准方法，并提高差异人群在医疗保健和结果方面的公平性。获得基因组医学研究、临床服务和公共卫生干预措施的机会减少，有可能加剧基因组医学方面的差异。本文的目的是描述基因组医学公平性面临的这些挑战，并确定解决这些问题的机会和未来方向。需要努力增强获得基因组医学研究、临床服务和公共卫生干预措施的机会，并且应该优先考虑对差异人群的精准医学的临床实用性进行额外研究，以确保基因组医学的公平性。
