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在基因组学研究中关注祖先多样性:一种促进发展中国家基于基因组学的医疗服务公平提供的潜在手段。

Focusing attention on ancestral diversity within genomics research: a potential means for promoting equity in the provision of genomics based healthcare services in developing countries.

作者信息

Sirisena Nirmala D, Dissanayake Vajira H W

机构信息

Human Genetics Unit, Faculty of Medicine, University of Colombo, Kynsey Road, Colombo 8, Sri Lanka.

出版信息

J Community Genet. 2017 Oct;8(4):275-281. doi: 10.1007/s12687-017-0311-y. Epub 2017 Jul 11.

DOI:10.1007/s12687-017-0311-y
PMID:28699077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5614882/
Abstract

Although we are well into the second decade after the completion of the International Human Genome Project, genomic research has failed to fully represent the diverse ancestry of global populations. The resultant healthcare challenges faced by populations underrepresented in genomic research needs to be tackled by the global scientific community. In this paper, we address several major factors which have contributed to the existing health disparity and put forward a combination of scientific and political interventions needed to bring about a change that will ensure all global populations benefit equally from the advances made in genomic medicine and research.

摘要

尽管国际人类基因组计划完成后已顺利进入第二个十年,但基因组研究仍未能充分体现全球人群的多样血统。基因组研究中代表性不足的人群所面临的医疗保健挑战,需要全球科学界加以应对。在本文中,我们探讨了导致现有健康差距的几个主要因素,并提出了一系列科学和政治干预措施,以实现变革,确保所有全球人群都能平等受益于基因组医学和研究的进展。

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