Kim Jaeho, Jung Sang-Hyuk, Choe Yeong Sim, Kim Soyeon, Kim Beomsu, Kim Hang-Rai, Son Sang Joon, Hong Chang Hyung, Na Duk L, Kim Hee Jin, Cho Soo-Jin, Won Hong-Hee, Seo Sang Won
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea; Samsung Alzheimer Research Center, Samsung Medical Center, Seoul, Republic of Korea; Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong-si, Gyeonggi-do, Republic of Korea.
Department of Digital Health, SAIHST, Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Neurobiol Aging. 2022 Jun;114:27-37. doi: 10.1016/j.neurobiolaging.2022.03.001. Epub 2022 Mar 7.
We investigated which factors might explain the differences between the frequencies of brain β-amyloid (Aβ) deposition in Korean and European cognitively normal individuals (CNs). We recruited 434 Korean CNs from the Samsung Medical Center (SMC) and 323 European CNs from the US Alzheimer's Disease Neuroimaging Initiative (ADNI). The Korean CNs showed lower education duration (11.8 ± 4.8 years vs. 16.8 ± 2.5 years, p < 0.001) than the European CNs. The frequency of Aβ (+) was higher in the European CNs (32.8%) than in the Korean CNs (20.0%; p < 0.001). In the SMC genome-wide association study (GWAS), 10 variants (including rs7481773 on chromosome 11, located near the brain-derived neurotrophic factor gene) exceeded the genome-wide significance level (p < 5 × 10). Especially, rs7481773 carriers showed more rapid decline in memory function than non-carriers (p = 0.048). However, this association was not observed in the ADNI GWAS. Our findings suggested that the different frequencies of Aβ (+) between CN Koreans and Europeans might be related to decreased cognitive reserve or genetic factors.
我们研究了哪些因素可能解释韩国认知正常个体（CNs）与欧洲认知正常个体脑β-淀粉样蛋白（Aβ）沉积频率之间的差异。我们从三星医疗中心（SMC）招募了434名韩国CNs，从美国阿尔茨海默病神经影像倡议（ADNI）招募了323名欧洲CNs。韩国CNs的受教育年限低于欧洲CNs（11.8±4.8年对16.8±2.5年，p<0.001）。欧洲CNs中Aβ（+）的频率高于韩国CNs（32.8%对20.0%；p<0.001）。在三星医疗中心的全基因组关联研究（GWAS）中，10个变异（包括位于11号染色体上靠近脑源性神经营养因子基因的rs7481773）超过了全基因组显著性水平（p<5×10）。特别是，rs7481773携带者的记忆功能衰退比非携带者更快（p=0.048）。然而，在ADNI的GWAS中未观察到这种关联。我们的研究结果表明，韩国CNs和欧洲人之间Aβ（+）频率的差异可能与认知储备降低或遗传因素有关。
