Department of Epidemiology and Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Clinical Epidemiology Unit, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan, 250012, Shandong, China.
Int J Behav Nutr Phys Act. 2022 Apr 2;19(1):42. doi: 10.1186/s12966-022-01283-3.
To assess the spatiotemporal variation in female breast cancer attributable to low physical activity (LPA) at a global scale from 1990 to 2019, which is essential to promote physical activity, as well as prevent and control breast cancer.
The number of deaths and disability-adjusted life years (DALYs), and the corresponding age-standardized rates (ASMR and ASDR) of LPA-related breast cancer in 204 countries and territories from 1990 to 2019 were retrieved from the Global Burden of Disease Study 2019 to measure the related breast cancer burden by age and region. The estimated annual percentage change (EAPC) was calculated to quantify the secular trend in breast cancer burden rates.
From 1990 to 2019, globally, both breast cancer deaths and DALYs attributable to LPA nearly doubled, although the corresponding ASMR and ASDR decreased slightly, with EAPC of -0.46 (95% confidence interval: -0.52, -0.40) and -0.44 (95% confidence interval: -0.49, -0.39), respectively. The LPA-related breast cancer burden varied considerably across the world, with the highest-burden rates in Oceania, Tropical Latin America and Caribbean, and the fastest growth in North Africa and Middle East. The ASMR and ASDR showed a logarithmic association with the Socio-demographic Index, and a temporally upward trend in most of 204 countries regardless of the Socio-demographic Index or the ASMR in 1990.
Despite a decline in LPA-related breast cancer burden achieved in many countries during the last 3 decades like Bermuda, Myanmar, USA and China, an increase still occurred in most of 204 countries and territories, such as Solomon Islands, Equatorial Guinea, Japan and India. The findings can bring greater awareness to the importance of promoting physical activity for the local government to control the attributable breast cancer burden.
评估全球范围内 1990 年至 2019 年低体力活动（LPA）导致的女性乳腺癌的时空变化，这对于促进体力活动以及预防和控制乳腺癌至关重要。
从 2019 年全球疾病负担研究中检索了 204 个国家和地区 1990 年至 2019 年与 LPA 相关的乳腺癌死亡人数和残疾调整生命年（DALY）以及相应的年龄标准化率（ASMR 和 ASDR），以按年龄和地区衡量相关乳腺癌负担。计算了估计的年变化百分比（EAPC），以量化乳腺癌负担率的时间趋势。
从 1990 年到 2019 年，全球范围内，与 LPA 相关的乳腺癌死亡人数和 DALY 几乎翻了一番，尽管相应的 ASMR 和 ASDR 略有下降，EAPC 分别为-0.46（95%置信区间：-0.52，-0.40）和-0.44（95%置信区间：-0.49，-0.39）。与 LPA 相关的乳腺癌负担在全球范围内差异很大，负担率最高的地区是大洋洲、热带拉丁美洲和加勒比地区，而北非和中东地区的增长最快。ASMR 和 ASDR 与社会人口指数呈对数关系，并且在大多数 204 个国家中，无论社会人口指数或 1990 年的 ASMR 如何，都呈现出时间上的上升趋势。
尽管过去 30 年中许多国家（如百慕大、缅甸、美国和中国）在降低与 LPA 相关的乳腺癌负担方面取得了进展，但在大多数 204 个国家和地区，如所罗门群岛、赤道几内亚、日本和印度，这种负担仍在增加。这些发现可以使地方政府更加意识到促进体力活动对于控制可归因于乳腺癌负担的重要性。
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