不同种族人群中间性高血糖的患病率差异及相关 2 型糖尿病的发病率：HELIUS 研究。

Differences in the prevalence of intermediate hyperglycaemia and the associated incidence of type 2 diabetes mellitus by ethnicity: The HELIUS study.

机构信息

Department of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, the Netherlands.

Department of Public and Occupational Health, Amsterdam University Medical Centre, Amsterdam, the Netherlands.

出版信息

Diabetes Res Clin Pract. 2022 May;187:109859. doi: 10.1016/j.diabres.2022.109859. Epub 2022 Mar 31.

DOI:10.1016/j.diabres.2022.109859

PMID:35367312

Abstract

AIMS

We aimed to describe differences in the prevalence of intermediate hyperglycaemia (IH) between six ethnic groups. Moreover, to investigate differences in the association of the classifications of IH with the incidence of T2DM between ethnic groups.

METHODS

We included 3759 Dutch, 2826 African Surinamese, 1646 Ghanaian, 2571 Turkish, 2691 Moroccan and 1970 South Asian Surinamese origin participants of the HELIUS study. IH was measured by fasting plasma glucose (FPG) and HbA1c. We calculated age-, BMI and physical-activity-adjusted prevalence of IH by sex, and calculated age and sex-adjusted hazard ratios (HR)for the association between IH and T2DM in each ethnic group.

RESULTS

The prevalence of IH was higher among ethnic minority groups (68.6-41.7%) than the Dutch majority (34.9%). The prevalence of IH categories varied across subgroups. Combined increased FPG and HbA1c was most prevalent in South-Asian Surinamese men (27.6%, 95 %CI: 24.5-30.9%), and in Dutch women (4.2%, 95 %CI: 3.4-5.1%). The HRs for T2DM for each IH-classification did not differ significantly between ethnic groups. HRs were highest for the combined classification, e.g., HR = 8.1, 95 %CI: 2.5-26.6 in the Dutch.

CONCLUSION

We found a higher prevalence of IH in ethnic minority versus majority groups, but did not find evidence for a differential association of IH with incident T2DM.

摘要

目的

我们旨在描述六种族裔之间中间性高血糖（IH）的患病率差异。此外，研究 IH 分类与各族裔 2 型糖尿病（T2DM）发病风险之间的关联差异。

方法

我们纳入了 HELIUS 研究中的 3759 名荷兰人、2826 名非洲苏里南人、1646 名加纳人、2571 名土耳其人、2691 名摩洛哥人和 1970 名南亚苏里南人。IH 通过空腹血糖（FPG）和糖化血红蛋白（HbA1c）来测量。我们按性别计算了年龄、BMI 和体力活动调整后的 IH 患病率，并计算了每个族裔中 IH 与 T2DM 之间关联的年龄和性别调整后的风险比（HR）。

结果

少数民族群体的 IH 患病率高于荷兰多数族裔（68.6-41.7%比 34.9%）。IH 类别在亚组之间的患病率有所不同。南亚苏里南男性（27.6%，95%CI：24.5-30.9%）和荷兰女性（4.2%，95%CI：3.4-5.1%）中联合升高的 FPG 和 HbA1c 最为常见。每种 IH 分类的 T2DM HR 在族裔群体之间没有显著差异。联合分类的 HR 最高，例如，荷兰人群的 HR=8.1，95%CI：2.5-26.6。