Li Rui, Zhu Xinyi, Zheng Zhiwei, Wang Pengyun, Li Juan
Center on Aging Psychology, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Center on Aging Psychology, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Neuropsychologia. 2020 Apr;141:107393. doi: 10.1016/j.neuropsychologia.2020.107393. Epub 2020 Feb 11.
The feeling of happiness is beneficial for both mental and physical health. Based on the findings of previous studies that reported that the insular cortex is a crucial region for subjective feelings, including happiness, in this study, we further identified the subregion of the insula and its functional connectivity associated with subjective well-being (SWB). Using an iterative seed-target-seed approach, we labelled the posterior, dorsal, and ventral anterior insular regions of interest (ROIs) and evaluated the association between functional connectivity of each of these insular ROIs and the self-reported SWB in a group of 75 healthy elderly adults. We demonstrated that the functional connectivity of the dorsal anterior insula (dAI) was significantly correlated with SWB. This relationship was negative and unique for the functional connectivity of left dAI with specific regions from the default-mode network, including the anterior medial prefrontal cortex and inferior parietal lobe. Our result suggested a functional connectivity network of the left dAI with specific DMN brain regions, suggesting the neural basis of SWB.
幸福感对身心健康都有益处。基于先前研究的结果，这些研究报告称脑岛皮质是包括幸福感在内的主观感受的关键区域，在本研究中，我们进一步确定了脑岛的子区域及其与主观幸福感（SWB）相关的功能连接。使用迭代种子-目标-种子方法，我们标记了感兴趣的脑岛后区、背侧区和腹侧前区（ROIs），并评估了一组75名健康老年人中这些脑岛ROIs各自的功能连接与自我报告的SWB之间的关联。我们证明背侧前脑岛（dAI）的功能连接与SWB显著相关。这种关系对于左dAI与默认模式网络特定区域（包括前内侧前额叶皮质和顶下小叶）的功能连接来说是负向且独特的。我们的结果表明左dAI与特定默认模式网络脑区之间存在功能连接网络，提示了主观幸福感的神经基础。
