大肠杆菌中的谷胱甘肽对于抵抗过氧化氢和γ辐射并非必需。
Glutathione in Escherichia coli is dispensable for resistance to H2O2 and gamma radiation.
作者信息
Greenberg J T, Demple B
出版信息
J Bacteriol. 1986 Nov;168(2):1026-9. doi: 10.1128/jb.168.2.1026-1029.1986.
Abstract
Escherichia coli devoid of glutathione (because of transposon insertions in the gshA gene) has normal resistance to H2O2, cumene hydroperoxide, heat, or ionizing radiation. Intracellular glutathione thus does not protect E. coli from such lethal oxidative damage. The use of gshA::Tn10 mutants also revealed a glutathione-independent, H2O2-inducible resistance to N-ethylmaleimide.
摘要
缺乏谷胱甘肽的大肠杆菌（由于gshA基因中的转座子插入）对过氧化氢、氢过氧化苯异丙酯、热或电离辐射具有正常抗性。因此，细胞内的谷胱甘肽并不能保护大肠杆菌免受此类致命的氧化损伤。使用gshA::Tn10突变体还揭示了一种不依赖谷胱甘肽的、对N-乙基马来酰亚胺的过氧化氢诱导抗性。
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